BBSRC Portfolio Analyser

Investigator / Supervisor details

NameProfessor Nigel Scrutton
Current InstitutionThe University of Manchester
Current DepartmentChemistry
Institution websitehttp://www.man.ac.uk
Previous InstitutionsUniversity of Leicester

Current Awards

ReferenceTitleAward RoleValue £Type
BB/W019779/1 Integrated bioreactor platform for rapid scale-up and translation Co-investigator 553,682 Research Grant
BB/W019841/1 Optima Analytical Ultracentrifuge for mechanistic insights into complex protein binding events Co-investigator 261,107 Research Grant
BB/W019892/1 Advancing 'omics analysis with a Sciex ZenoToF 7600 mass spectrometer Co-investigator 712,101 Research Grant
BB/X003027/1 Generalised Photocatalysis by Enzymes (GENPENZ) Principal Investigator 3,178,051 Research Grant

Completed Awards

ReferenceTitleAward RoleValue £Type
00/A2/B/06218 Mechanistic studies of pentaerythritul tetranitrate reductase Principal Supervisor 37,091 Studentships
00/B1/B/06223 Mechanisms of enzymatic hydrogen tunnelling: ground state tunnelling driven by protein dynamics Principal Supervisor 37,091 Studentships
01/B1/C/07225 Quantitative and dynamical aspects of protein-protein interactions in ET complex assembly Principal Supervisor 39,359 Studentships
96/A1/B/02243 Mechanisms of opiate catabolising flavoproteins Principal Supervisor 31,585 Studentships
96/B1/B/02246 Engineering trimethylamine dehydrogenase toward new amine substrates Principal Supervisor 31,585 Studentships
98/B1/C/04258 Studying the role of domain motion in the function of electron transferring flavoprotein Principal Supervisor 33,592 Studentships
99/B1/C/05209 Enzymology of macrophage NADPH oxidase and activating cell signalling proteins Principal Supervisor 35,135 Studentships
B16808 Deconvoluting the electron transfer pathway in flavocytochrome P450 BM3 Co-investigator 200,428 Research Grant
B18118 Structures of short-lived physiological electron transfer complexes Co-investigator 163,852 Research Grant
B18118/2 Structures of short-lived physiological electron transfer complexes Co-investigator 27,751 Research Grant
B19724 Quantum catalysis in enzymes - beyond the transition state theory paradigm Principal Investigator 383,354 Research Grant
B19724/2 Quantum catalysis in enzymes - beyond the transition state theory paradigm Principal Investigator 169,002 Research Grant
BB/C003896/1 Atomic analysis of promoting vibrations in the vibrationally assisted model of enzymic hydrogen tunneling. Principal Investigator 483,422 Research Grant
BB/C00390X/1 Mechanistic basis of uphill electron transfer and reductive methylation in the human MS¿MSR electron transfer complex Principal Investigator 237,482 Research Grant
BB/C00390X/2 Mechanistic basis of uphill electron transfer and reductive methylation in the human MSMSR electron transfer complex Principal Investigator 185,304 Research Grant
BB/C006879/1 Construction of a biotechnologically versatile and stable oxygenase biocatalyst Co-investigator 209,305 Research Grant
BB/C006879/2 Construction of a biotechnologically versatile and stable oxygenase biocatalyst Co-investigator 193,248 Research Grant
BB/C008294/1 Elucidating the role of radical chemistry in the mechanism of action of monoamine oxidase. Principal Investigator 276,756 Research Grant
BB/C511305/1 Computing infrastructure to underpin integrated and predictive structural and systems biology Co-investigator 100,611 Research Grant
BB/D01963X/1 Interdisciplinary approaches to elucidating fundamental reactive processes in enzyme systems using novel fast reaction methods. Principal Investigator 798,351 Fellowships
BB/D524608/1 A high brilliance X-ray generator with CCD detector for the Manchester Interdisciplinary Biocentre Co-investigator 199,800 Research Grant
BB/E00833X/1 High pressure & low temperature study of the mechanism of enzymatic hydrogen tunnelling: promoting motions vs multiple kinetically distinct substates Principal Investigator 86,082 Research Grant
BB/E010717/1 A generic biocatalytic reaction platform for the stereospecific reduction and oxidation of alkenes Principal Investigator 1,704,123 Research Grant
BB/E013007/1 A Biological Pulsed EPR/ENDOR Facility for the Manchester Interdisciplinary Biocentre Co-investigator 240,000 Research Grant
BB/E017010/1 Substrate channelling in catabolism of methylated amines Co-investigator 681,729 Research Grant
BB/F000537/1 Dynamically-coupled enzyme catalysis: towards a step change in our understanding of enzyme catalysed reactions Principal Investigator 2,402,423 Research Grant
BB/F002521/1 Novel routes to catalytic intermediates in the cytochrome P450 catalytic cycle Co-investigator 520,651 Research Grant
BB/F004397/1 Reflection anisotropy spectroscopy as a new tool for linking macromolecular conformation to biological function: applications in biological redox chem Principal Investigator 354,969 Research Grant
BB/F00883X/1 Directed evolution approaches to generation of an industrially applicable biocatalyst Co-investigator 587,704 Research Grant
BB/G001383/1 The dynamics of complex cellular machinery required for methionine synthesis in mammalian cells Principal Investigator 528,887 Research Grant
BB/G005850/1 Elucidating mechanisms of proton coupled and conformationally coupled electron transfer in redox enzymes catalysis Principal Investigator 324,671 Research Grant
BB/G008558/1 A novel regulator of human apoptosis Co-investigator 548,111 Research Grant
BB/H000577/1 Domain motion coupled to radical catalysis in ornithine aminomutase Co-investigator 398,351 Research Grant
BB/H000844/1 Atomic resolution experimental interrogation of hydride quantum tunnelling in enzyme reaction chemistry Co-investigator 414,672 Research Grant
BB/H006265/1 Elucidating and exploiting cytochrome P450 TxtE-catalysed tryptophan nitration in thaxtomin phytotoxin biosynthesis Co-investigator 17,505 Research Grant
BB/H017208/1 Towards a systems-level understanding of the novel redox-regulated mitochondrial protein import and disulphide bond formation pathway Co-investigator 347,186 Research Grant
BB/I015779/1 Development of biocatalytic ene reductase toolkits for stereospecific reductions through evolution of flavoprotein oxidoreductases. Principal Investigator 91,932 Training Grants
BB/I019928/1 Dynamic structural science: exploring energy landscapes in complex enzyme systems Principal Investigator 341,247 Research Grant
BB/I020543/1 Acceleration and control of spin-restricted oxygenation by cofactor-independent dioxygenases Principal Investigator 340,055 Research Grant
BB/J011657/1 Conformational kinetics in diflavoproteins: a new approach using photo-initiated time-resolved continuous flow EPR spectroscopy. Principal Investigator 92,173 Training Grants
BB/J015512/1 Industrial chemicals of the monoterpenoid class realised through synthetic biology and pathway engineering Principal Investigator 710,975 Research Grant
BB/K00199X/1 Rapid Evolution of Enzymes and Synthetic Micro-organisms for the Development of Industrial Biocatalysts Co-investigator 3,604,052 Research Grant
BB/K017802/1 In vivo alpha-olefin production: a sustainable hydrocarbon source Co-investigator 606,412 Research Grant
BB/L010798/1 Synthetic Biology for Biotechnology of Fine Chemicals - SynBioTech Principal Investigator 25,407 Research Grant
BB/L014335/1 The Research Complex at Harwell LIFEtime Instrument Co-investigator 828,604 Research Grant
BB/L014823/1 Multi-purpose instrument for advanced Raman spectroscopy techniques Co-investigator 409,322 Research Grant
BB/L015048/1 Hydrogen/Deuterium Exchange and Ion Mobility Mass Spectrometry to Underpin Research on Protein Interactions Co-investigator 498,947 Research Grant
BB/L027593/1 13 ERA IB TERPENOSOME: Engineered compartments for monoterpenoid production using synthetic biology Co-investigator 697,624 Research Grant
BB/M000354/1 Innovative Routes to Monoterpene Hydrocarbons and Their High Value Derivatives Principal Investigator 3,038,984 Research Grant
BB/M007065/1 Heavy enzymes: Probing fast dynamics in enzyme catalysis by mass modulation Co-investigator 383,665 Research Grant
BB/M011658/1 An advanced multi-purpose instrument for biological ultrafast time resolved spectroscopy Principal Investigator 491,200 Research Grant
BB/M017702/1 CENTRE FOR SYNTHETIC BIOLOGY OF FINE AND SPECIALITY CHEMICALS Principal Investigator 10,198,943 Research Grant
BB/N004868/1 An analysis of the commercial potential of menthol production using synthetic biology approaches. Principal Investigator 9,480 Research Grant
BB/N006275/1 Molecular mechanism and engineering of P450 peroxygenases for synthetic biology applications Co-investigator 462,081 Research Grant
BB/N012356/1 Feasibility study to determine whether new generation catalytic antibodies can overcome existing limitations for future use in clinical settings. Principal Investigator 119,422 Research Grant
BB/N013980/1 Why does Nature use modular enzyme architectures for biological catalysis? Principal Investigator 346,806 Research Grant
BB/N503976/1 Synthetic biology applications of a new generation of antibody catalysts Principal Investigator 95,042 Training Grants
BB/P000622/1 Exploring the biotechnological potential of the UbiD (de)carboxylase family: novel biochemistry for renewable commodity chemicals Co-investigator 585,505 Research Grant
BB/R000220/1 A new generation of Crystallographic detector for Multi-user Barkla X-ray laboratory Co-investigator 219,626 Research Grant
BB/R013497/1 A versatile proton transfer reaction-mass spectrometry platform for online monitoring of VOCs. Principal Investigator 453,088 Research Grant
BB/R505894/1 Biocatalyst parts evaluation and pathway refactoring for synthetic drug manufacture Principal Investigator 98,212 Training Grants
BB/S011684/1 Newton Bhabha Industrial Waste: Integrated biorefinery for converting paper mill waste into chemical wealth (waste-2-wealth) Principal Investigator 420,027 Research Grant
BB/T017473/1 A nanosecond laser spectroscopy platform for studying light-activated biomolecules Principal Investigator 338,507 Research Grant
BB/T017643/1 Glacios cryo-electron microscope for single particle analysis and electron tomography of proteins, complexes and fibrillar assemblies Co-investigator 750,000 Research Grant
BBS/B/03572 Conformational signalling in dynamic multi-domain electron transfer complexes Principal Investigator 376,361 Research Grant
BBS/B/03572/2 Conformational signalling in dynamic multi-domain electron transfer complexes Principal Investigator 258,478 Research Grant
BBS/B/06288 Molecular enzymology of FprA - a pivotal enzyme in M. tuberculosis redox chemistry Co-investigator 207,930 Research Grant
BBS/B/06288/2 Molecular enzymology of FprA - a pivotal enzyme in M. tuberculosis redox chemistry Co-investigator 116,783 Research Grant
BBS/B/1311X Conformational equilibria and electron transfer in NADPH-cytochrome P450 reductase Co-investigator 223,004 Research Grant
BBS/S/A/2004/10948 Membrane-bound ETF ubiquinone oxidoreductase conformational signalling and electron transfer complex assembly Principal Supervisor 13,614 Studentships
BBS/S/B/2004/12612 Membrane-bound ETF ubiquinone oxidoreductase, conformational signalling and electron transfer complex assembly Principal Supervisor 34,009 Studentships
BBS/S/H/2005/11986 A chemical genetics approach to understanding mechanisms of cellular protein assembly Principal Supervisor 45,472 Studentships
BBS/S/P/2003/10346 Quantum tunneling mechanisms of H-transfer in narcotic specific enzymes Principal Supervisor 13,842 Studentships
BBS/S/P/2003/10346A Quantum tunnelling mechanisms of H-transfer in narcotic specific enzymes Principal Supervisor 12,405 Studentships
C10848 Role of large-scale structural reorganisation in interprotein electron transfer Principal Investigator 160,992 Research Grant
C11813 Elucidating the mechanism of enzymatic hydrogen tunnelling Principal Investigator 193,848 Research Grant
C13573 Elucidating the mechanism of explosive degradation by PETN reductase Principal Investigator 155,056 Research Grant
C13574 Elucidating the mechanism of explosive degradation by PETN reductase Co-investigator 27,951 Research Grant
C16349 Electron transfer in dihydroorotate dehydrogenase B: a novel flavoprotein and antimicrobial target Principal Investigator 191,652 Research Grant
C18194 Radical reappraisal of the mechanism of electron transfer and the role of calmodulin in nitric synthase Principal Investigator 171,568 Research Grant
C18194/2 Radical reappraisal of the mechanism of electron transfer and the role of calmodulin in nitric synthase Principal Investigator 26,388 Research Grant
C19031 Elucidating factors controlling enzymic H-tunnelling through structural and kinetic studies of dimethylglycine oxidase Principal Investigator 190,784 Research Grant
C19031/2 Elucidating factors controlling enzymic H-tunnelling through structural and kinetic studies of dimethylglycine oxidase Principal Investigator 72,367 Research Grant
C19757 Elucidating enzyme mechanism and physiological role of a key P450 enzyme (CYP121) from mycobacterium tuberculosis Co-investigator 196,872 Research Grant
C19757/2 Elucidating enzyme mechanism and physiological role of a key P450 enzyme (CYP121) from mycobacterium tuberculosis Co-investigator 86,688 Research Grant
E02741 New catalysts for the analysis of bioactive amines Principal Investigator 152,803 Research Grant
E09215 Strategic engineering of morphinone reductase and PETN reductase for biotransformation and biosensor applications Co-investigator 189,990 Research Grant
E09216 Strategic engineering of morphinone reductase and PETN reductase for biotransformation and biosensor applications Principal Investigator 173,786 Research Grant
JEI09276 Conformational analysis of biomolecules by CD spectroscopy: structural and dynamic studies Principal Investigator 42,504 Research Grant
REI20488 Isothermal titration calorimetry: novel and established applicatons in redox enzymology Principal Investigator 29,252 Research Grant
SBD07458 New diagnostic enzymes via the strategic manipulation of electron tunnelling pathways Principal Investigator 148,292 Research Grant
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