Award details

Elucidating the mechanism of enzymatic hydrogen tunnelling

Reference	C11813
Principal Investigator / Supervisor	Professor Nigel Scrutton
Co-Investigators / Co-Supervisors	Professor Michael Sutcliffe
Institution	University of Leicester
Department	Biochemistry
Funding type	Research
Value (£)	193,848
Status	Completed
Type	Research Grant
Start date	01/08/2000
End date	01/08/2003
Duration	36 months

Abstract

This proposal lies at the very heart, and fundamentally challenges our current understanding, of biological catalysis. We aim to elucidate the mechanism of hydrogen tunnelling in enzymes, with particular emphasis on the hitherto overlooked yet pivotal role of protein dynamics. We aim to provide for the first time experimental verification of the generality of a new vibrationally enhanced ground state tunnelling theory for enzymatic hydrogen transfer that we have proposed for methylamine dehydrogenase. Our work aims to show a pivotal role for Ground State Quantum Tunnelling in enzyme catalysis, thus challenging the indiscriminate and widespread use of both transition state theory and its tunnelling derivatives.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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