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New diagnostic enzymes via the strategic manipulation of electron tunnelling pathways
Reference
SBD07458
Principal Investigator / Supervisor
Professor Nigel Scrutton
Co-Investigators /
Co-Supervisors
Professor Michael Sutcliffe
Institution
University of Leicester
Department
Biochemistry
Funding type
Research
Value (£)
148,292
Status
Completed
Type
Research Grant
Start date
01/10/1997
End date
01/10/2000
Duration
36 months
Abstract
Three inter-related lines of inquiry on electron transfer in Trimethylamine Dehydrogenase will be followed. These include (i) a detailed investigation of bridging protein structure in electron transfer reactions, (ii) a study of surface residues that mediate electron transfer from the enzyme to its physiological redox partner and (iii) the display of oxygen sensitive redox centres on the surface of the enzyme enabling the enzyme to be readily used in diagnostic environments.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Structural biology and design applications (SBD) [1996]
Funding Scheme
X – not Funded via a specific Funding Scheme
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