Award details

Electron transfer in dihydroorotate dehydrogenase B: a novel flavoprotein and antimicrobial target

Reference	C16349
Principal Investigator / Supervisor	Professor Nigel Scrutton
Co-Investigators / Co-Supervisors	Professor Andrew Munro
Institution	University of Leicester
Department	Biochemistry
Funding type	Research
Value (£)	191,652
Status	Completed
Type	Research Grant
Start date	18/04/2002
End date	13/07/2005
Duration	39 months

Abstract

Dihydroorotate dehydrogenase B is a novel iron-sulphur flavoprotein and an important chemotherapeutic target. The structure has been solved by crystallographic methods. We shall develop a detailed understanding of the mechanism of the enzyme using transient kinetic and potentiometric methods to identify the key reaction intermediates and to elucidate the mechanism of bi-directional electron flow. These studies will provide the first detailed mechanistic account of the reaction catalysed by this enzyme and will underpin studies of inhibitor design against this important enzyme target. The project will make a significant contribution to our knowledge of the control of biological electron transfer via prototropic control mechanisms.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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