Award details

Streptomyces coelicolor as a model for the end-user driven exploitation of a genome sequence

Reference	EGH16080
Principal Investigator / Supervisor	Professor Mark Buttner
Co-Investigators / Co-Supervisors	Professor Keith Chater, Dr Andrew Hesketh, Dr Robert Sawers
Institution	John Innes Centre
Department	John Innes Centre Department
Funding type	Research
Value (£)	873,732
Status	Completed
Type	Research Grant
Start date	01/10/2002
End date	31/01/2007
Duration	52 months

Abstract

The objectives of this proposal are to exploit two recent major technical breakthroughs, efficient in vivo transposition and rapid PCR-directed gene disruption, to begin to construct a comprehensive, defined knockout library for all non- essential genes in S. coelicolor, and to apply the new technologies to (i) explore the secondary metabolic potential of the genome (ii) analyse gene expression and metabolism under oxygen limitation (iii) define all the genes required for morphological differentiation, and (iv) characterise the Tat secretion pathway. (Joint with grants 88/EGH16081 and 83/EGH16082).

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Exploiting Genomics: Healthcare, Pharmaceuticals (EGH) [2001]
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

EGH16081 Streptomyces Coelicolor as a model for the end-user driven exploitation of a genome sequence

EGH16082 Streptomyces coelicolor as a model for the end-user driven exploitation of a genome sequence

EGH18395 Streptomyces coelicolor as a model for the end- user driven exploitation of a genome sequence

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