Award details

Streptomyces Coelicolor as a model for the end-user driven exploitation of a genome sequence

Reference	EGH16081
Principal Investigator / Supervisor	Professor Gregory Challis
Co-Investigators / Co-Supervisors
Institution	University of Warwick
Department	Chemistry
Funding type	Research
Value (£)	250,244
Status	Completed
Type	Research Grant
Start date	15/02/2003
End date	14/07/2006
Duration	41 months

Abstract

The objectives of this proposal are to exploit two recent major technical breakthroughs, efficient in vivo transposition and rapid PCR-directed gene disruption, to begin to construct a comprehensive, defined knockout library for all non- essential genes in S. coelicolor, and to apply the new technologies to (i) explore the secondary metabolic potential of the genome (ii) analyse gene expression and metabolism under oxygen limitation (iii) define all the genes required for morphological differentiation, and (iv) characterise the Tat secretion pathway. (Joint with grants 208/EGH16080 and 83/EGH16082).

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Exploiting Genomics: Healthcare, Pharmaceuticals (EGH) [2001]
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

EGH16080 Streptomyces coelicolor as a model for the end-user driven exploitation of a genome sequence

EGH16082 Streptomyces coelicolor as a model for the end-user driven exploitation of a genome sequence

EGH18395 Streptomyces coelicolor as a model for the end- user driven exploitation of a genome sequence

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search