Award details

Streptomyces coelicolor as a model for the end- user driven exploitation of a genome sequence

Reference	EGH18395
Principal Investigator / Supervisor	Professor Paul Dyson
Co-Investigators / Co-Supervisors	Dr Paul Herron
Institution	Swansea University
Department	School of the Environment and Society
Funding type	Research
Value (£)	362,612
Status	Completed
Type	Research Grant
Start date	01/01/2003
End date	01/05/2006
Duration	40 months

Abstract

The objectives of this proposal are to exploit two recent major technical breakthroughs - efficient transposition and rapid PCR- directed gene disruption - to begin to construct a comprehensive, defined knockout library for all non-essential genes in S. coelicolor, and to apply the new technologies to (i) to explore the secondary metabolic potential of the genome (ii) analyse gene expression and metabolism under oxygen limitation, (iii) define all the genes required for morphological differentiation, and (iv) characterise the Tat secretion pathway.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Exploiting Genomics: Healthcare, Pharmaceuticals (EGH) [2001]
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

EGH16080 Streptomyces coelicolor as a model for the end-user driven exploitation of a genome sequence

EGH16081 Streptomyces Coelicolor as a model for the end-user driven exploitation of a genome sequence

EGH16082 Streptomyces coelicolor as a model for the end-user driven exploitation of a genome sequence

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search