BBSRC Portfolio Analyser

Investigator / Supervisor details

NameProfessor Len Stephens
Current InstitutionBabraham Institute
Current DepartmentSignalling
Institution websitehttp://www.babraham.ac.uk
Previous Institutions

Current Awards

ReferenceTitleAward RoleValue £Type
BBS/E/B/000C0431 How neutrophils detect and resolve infection and how this deteriorates with age Co-investigator 4,873,310 Institute Project
BBS/E/B/000C0432 How changes in nutrient availability are sensed and shape metabolism and growth Co-investigator 7,076,740 Institute Project
BBS/E/B/000C0433 Signalling mechanisms that determine the rate of ageing Co-investigator 3,727,794 Institute Project
BBS/E/B/000C0434 How autophagy and related processes are coordinated and important in adaption to changed nutrient availability and cell damage Co-investigator 5,452,381 Institute Project

Completed Awards

ReferenceTitleAward RoleValue £Type
02/A1/C/08443 The role of P13Ks in chemotaxis Principal Supervisor 41,845 Studentships
B11586 Synthesis of phosphoinositides as biological probes for downstream protein effectors Co-investigator 170,356 Research Grant
BB/D013593/1 Regulation of the Ras cycle in neutrophils Principal Investigator 266,214 Research Grant
BB/H530754/1 BBSRC Industrial CASE Partnership Grant Principal Investigator 73,110 Training Grants
BB/I003916/1 How do cells shape and interpret PIP3 signals? Principal Investigator 1,072,398 Research Grant
BB/I008489/1 A 3-D perspective on neutrophil migration Principal Investigator 516,935 Research Grant
BB/K501712/1 PI lipids: modulation by PI kinases and phosphatases Principal Investigator 92,173 Training Grants
BB/T002530/1 Molecular species variants of phospholipids: a code through which cells distinguish phosphoinositide signals and their synthetic intermediates Co-investigator 449,965 Research Grant
BBS/B/01979 P13K and Vav-dependent regulation of Rac activation reactive oxygen species production and phagocytosis by neutrophils Principal Investigator 219,477 Research Grant
BBS/E/B/00001139 Phosphoinositide structural analysis Principal Investigator 591,100 Institute Project
BBS/E/B/00001155 PtdIns(3,4,5)P3 binding proteins Principal Investigator 888,405 Institute Project
BBS/E/B/00001180 PtdIns(3,4,5) P3 regulation of a novel Rho-family GAP protein Principal Investigator 575,958 Institute Project
BBS/E/B/00001181 PtdIns(3,4,5)P3 and superoxide formation Principal Investigator 564,076 Institute Project
BBS/E/B/0000C197 Analysis of Ca2+-triggered Ras GTPase-activating protein function Co-investigator 649,357 Institute Project
BBS/E/B/0000C238 The regulation of neutrophil chemotaxis Principal Investigator 81,354 Institute Project
BBS/E/B/0000F106 Portuguese Government Studentship: PI3K signaling in neutrophils related to the regulation of superoxide formation by ras and PI3K Principal Investigator 60,404 Institute Project
BBS/E/B/0000H052 Ras dependent PI3K Principal Investigator 168,494 Institute Project
BBS/E/B/0000H054 Role of PI3K in regulation of superoxide formation Principal Investigator 191,706 Institute Project
BBS/E/B/0000H183 Role of the Small GTPase RhoG in Neutrophil Activation Principal Investigator 124,627 Institute Project
BBS/E/B/0000H234 Understanding the regulation of Polycomb Repressor Complex 1 and its role in epigenetic control of gene expression Principal Investigator 243,115 Institute Project
BBS/E/B/0000H235 P13K signalling; the rules of engagement Principal Investigator 264,012 Institute Project
BBS/E/B/0000L091 The molecules and mechanisms that deliver polarised Ptdins(3,4,5)P3 accumulation. Principal Investigator 179,722 Institute Project
BBS/E/B/0000L106 Understanding the spatio-temporal control of Ras deactivation by Ca2+ Co-investigator 110,596 Institute Project
BBS/E/B/0000L110 PI3K and Vav-dependent regulation of Rac activation, reactive oxygen species production and phagocytosis by neutrophils Principal Investigator 136,149 Institute Project
BBS/E/B/0000L172 Regulation of the Ras cycle in neutrophils Principal Investigator 126,974 Institute Project
BBS/E/B/0000L751 Babraham/European studentship: Regulation of PI3 kinase gamma in vivo Principal Investigator 95,212 Institute Project
BBS/E/B/0000L968 BBSRC DTA Studentship : Crystallographic and functional studies of a Ca2+ triggered Ras GTPase activating protein Principal Investigator 37,341 Institute Project
BBS/E/B/0000L986 BBSRC DTA CASE Studentship: Development of Lentivirus-delivered RNAi to study the roles of PI3Ks in inflammatory responses of primary cells and in the murine bone marrow compartment Principal Investigator 225,189 Institute Project
BBS/E/B/0000N397 The role of p101 regulating subunit of PI3Kgamma in neutrophil function Principal Investigator 12,277 Institute Project
BBS/E/B/0000S239 EU FP7-Analysis of the TRPV2 calcium channel in inflammation Principal Investigator 53,218 Institute Project
BBS/E/B/000C0411 Towards an integrated understanding of neutrophil biology and their role in resisting infection Principal Investigator 3,762,311 Institute Project
BBS/E/B/000C0413 To map the organisation of nutrient signalling pathways Principal Investigator 3,580,157 Institute Project
BBS/E/B/000C0415 The development of a powerful new lipidomics tool kit underpinning our objectives Principal Investigator 1,227,814 Institute Project
BBS/E/B/000C0417 To define the molecular mechanisms that determine cellular and organismal longevity Principal Investigator 2,019,869 Institute Project
BBS/E/B/000C0419 A systems approach to understanding lipid, Ca2+ and MAPK signalling networks Principal Investigator 1,314,409 Institute Project
BBS/E/B/52001037 Inositol lipid metabolism. Principal Investigator 17,741 Institute Project
BBS/E/B/52001038 Intracellular signalling via phosphoinositide 3-kinases. Principal Investigator 35,481 Institute Project
BBS/E/B/52001156 Structure/function of p101/p110 gamma-P13K Principal Investigator 480,622 Institute Project
BBS/E/B/52896761 Regulation of superoxide production by rac and PI3K. Principal Investigator 54,593 Institute Project
BBS/E/B/52947757 Cell surface receptor regulation of the subcellular localisation of p101-p120 PI3K. Principal Investigator 49,276 Institute Project
BBS/E/B/52986397 Development of a p101 knock-out mouse Principal Investigator 9,064 Institute Project
BBS/S/D/2004/12651 Inflammatory signalling pathways in neutrophils and related cells (Funded via Training Grant BB/B511900/1) Principal Supervisor Studentships
BBS/S/D/2005/13229 Inflammatory signalling in the bone marrow (Funded via Training Grant BB/B511900/1) Principal Supervisor Studentships
BBS/S/L/2003/10264 Affinity isolation of disease-relevant phosphoinositide-binding proteins from Altzheimer and atherosclerosis tissues Principal Supervisor 44,824 Studentships
C20177 The molecules and mechanisms that deliver polarised PtdIns(345)P3 accumulation during chemotaxis Principal Investigator 247,678 Research Grant
GAN13064 Genomic and proteomic analysis of PI3K-targets Co-investigator 284,904 Research Grant
ICR07551 The molecular mechanisms which underlie the role of phosphoinositide 3-kinase (PI3K) and the monomeric GTPase rac as an intracellular signalling cassette Principal Investigator 138,480 Research Grant
REI18418 Investigation of neutrophil oxidase regulation and calcium signalling using multi-spectral confocal microscopy Co-investigator 98,900 Research Grant
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