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The molecules and mechanisms that deliver polarised PtdIns(345)P3 accumulation during chemotaxis
Reference
C20177
Principal Investigator / Supervisor
Professor Len Stephens
Co-Investigators /
Co-Supervisors
Dr Phillip Hawkins
,
Dr Sabine Suir
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
247,678
Status
Completed
Type
Research Grant
Start date
01/09/2003
End date
31/05/2007
Duration
45 months
Abstract
Receptor-stimulated, polarised accumulation of PtdIns(3,4,5)P2 at the leading edge of cells is now accepted to be a key component of the cellular compass that cells use to orientate chemotaxis. Mammalian neutrophils display amongst the most efficient and rapid chemotactic responses towards ligands that activate G-proteins. These responses, which are critical for normal inflammatory reactions, are dependant to various extents on P13Kgamma, Rho-family GTPases and p38MAPK activity; however, it is not clear how these signals are integrated. We propose to measure PtdIns (3,4,5) P3 and PtdIns (3,4) P2 distribution and accumulation in chemotaxing mouse neutrophils and will use a variety of approaches/resources to address how this dynamic, vector-defining signal is generated and regulated in space and time by external chemo attractants.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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