BBSRC Portfolio Analyser

Investigator / Supervisor details

NameDr Simon Cook
Current InstitutionBabraham Institute
Current DepartmentSignalling
Institution websitehttp://www.babraham.ac.uk
Previous Institutions

Current Awards

ReferenceTitleAward RoleValue £Type
BB/R021341/1 US Partnering Award: Cellular heterogeneity, signalling and decision-making in human pluripotent stem cells Co-investigator 48,164 Research Grant
BB/S017062/1 Investigating the targets and biological roles of the deubiquitylase USP43 Principal Investigator 348,247 Research Grant
BB/T50855X/1 Unbiased determination of BRAF variants modulating BRAF - CRAF dimerisation and MAPK signalling Principal Investigator 100,279 Training Grants
BB/X511572/1 Interrogating the function of deubiquitylases Principal Investigator 105,984 Training Grants
BBS/E/B/000C0431 How neutrophils detect and resolve infection and how this deteriorates with age Principal Investigator 4,873,310 Institute Project
BBS/E/B/000C0432 How changes in nutrient availability are sensed and shape metabolism and growth Principal Investigator 7,076,740 Institute Project
BBS/E/B/000C0433 Signalling mechanisms that determine the rate of ageing Principal Investigator 3,727,794 Institute Project
BBS/E/B/000C0434 How autophagy and related processes are coordinated and important in adaption to changed nutrient availability and cell damage Principal Investigator 5,452,381 Institute Project

Completed Awards

ReferenceTitleAward RoleValue £Type
01/A1/C/07516 Use of conditional mutants to study the role of SAPK cascades Principal Supervisor 39,359 Studentships
02/B1/C/08447 Sequestration of pro-apoptotic Bcl-2 proteins by molecular motors Principal Supervisor 41,845 Studentships
98/A1/C/04625 Regulation of AP-1 by MAP kinase pathways Principal Supervisor 33,602 Studentships
99/A1/C/05533 Regulation of cell growth, survival and motility by stress kinase signalling modules Principal Supervisor 35,171 Studentships
BB/C509190/1 The role of ERk5 in cell cycle arrest differentiation and senescence. Principal Investigator 211,540 Research Grant
BB/E02162X/1 How does ERK1/2-dependent phosphorylation target BimEL to the proteasome? Principal Investigator 354,889 Research Grant
BB/H530689/1 BBSRC Industrial CASE Partnership Grant Principal Investigator 73,110 Training Grants
BB/I003916/1 How do cells shape and interpret PIP3 signals? Co-investigator 1,072,398 Research Grant
BB/L008793/1 New insights into the function of the protein kinase DYRK1B, an ERK1/2 target gene Principal Investigator 322,649 Research Grant
BB/L016397/1 Identifying Deubiquitinases that regulate cell death and cell senescence Principal Investigator 94,126 Training Grants
BB/L502534/1 Targeting the IKK NFkB and TGF pathways to overcome resistance to targeted agents Principal Investigator 93,520 Training Grants
BB/N015886/1 Defining the role of ERK5 kinase and ERK5 transcriptional activities in cell migration and EMT using novel ERK5 inhibitors Principal Investigator 341,874 Research Grant
BB/P007015/1 DYRK protein kinases regulate p62/SQSTM1 to orchestrate cellular responses to oxidative stress, protein misfolding and nutrient starvation Principal Investigator 327,028 Research Grant
BB/T50807X/1 BBSRC NPIF Innovation Fellows Babraham Institute Principal Investigator 25,000 Training Grants
BB/W510920/1 The Babraham Institute 2021 Flexible Talent Mobility Account Principal Investigator 93,243 Training Grants
BBS/B/01111 A role for Pin1 in MAPK-dependent stabilisation of AP-1 proteins? Principal Investigator 194,973 Research Grant
BBS/E/B/00001199 Regulation of cell cycle progression by anti-proliferative signalling pathways Principal Investigator 324,191 Institute Project
BBS/E/B/0000C197 Analysis of Ca2+-triggered Ras GTPase-activating protein function Principal Investigator 649,357 Institute Project
BBS/E/B/0000C199 Regulation of cell proliferation and differentiation by protein kinase signalling pathways Principal Investigator 2,477,907 Institute Project
BBS/E/B/0000C224 Signalling pathway regulation of human and mouse cdx genes Co-investigator 199,197 Institute Project
BBS/E/B/0000C228 Signalling events that regulate Wallerian degeneration Co-investigator 213,920 Institute Project
BBS/E/B/0000H151 Bim as a determinant of cell death in human colorectal cancer cells Principal Investigator 61,965 Institute Project
BBS/E/B/0000H242 Role of ERK5 in cell transformation and P53 regulation Principal Investigator 80,888 Institute Project
BBS/E/B/0000H248 The role of Bcl-2 proteins in regulating metabolism in normal and tumour cells Principal Investigator 68,776 Institute Project
BBS/E/B/0000H413 The role and regulation of Fra-1 and JunB in Ras transformation Principal Investigator 96,521 Institute Project
BBS/E/B/0000H457 Transgenic approaches to defining the role of the stress-activated protein kinases, JNK and p38 in tumour progression Principal Investigator 299,041 Institute Project
BBS/E/B/0000L023 Regulation of the pro-apoptotic Bcl-2 protein Bim by MAPK pathways Principal Investigator 90,885 Institute Project
BBS/E/B/0000L106 Understanding the spatio-temporal control of Ras deactivation by Ca2+ Principal Investigator 110,596 Institute Project
BBS/E/B/0000L126 The role of ERK5 in cell cycle arrest, differentiation and senescence Principal Investigator 80,331 Institute Project
BBS/E/B/0000L134 A role for Pin1 in MAPK-dependent stabilization of AP-1 proteins ? Principal Investigator 135,440 Institute Project
BBS/E/B/0000L717 BBSRC/CASE studentship: Determinants of tumour cell sensitivity to PI3K and TOR pathway inhibitors Principal Investigator 130,430 Institute Project
BBS/E/B/0000L742 BBSRC DTG studentship: How do cells adapt to loss of ERK1/2 signalling? Principal Investigator 95,765 Institute Project
BBS/E/B/0000L744 BBSRC Industrial CASE Studentship: The role and regulation of the DYRK1b protein kinase Principal Investigator 98,017 Institute Project
BBS/E/B/0000L953 BBSRC Quota Studentship: Regulation of DUSP5 and DUSP6 expression in RAS and BRAF-dependent tumour cells Principal Investigator 12,923 Institute Project
BBS/E/B/0000L960 BBSRC Quota Studentship: Does Pin1 regulate MAPKAPK-2 ? Principal Investigator 9,876 Institute Project
BBS/E/B/0000L992 BBSRC DTA Studentship: MAP Kinases signals that regulate protein degradation Principal Investigator 114,122 Institute Project
BBS/E/B/0000Q033 Regulation of cyclin D, expression by MAPK and SAPK pathways Principal Investigator 38,993 Institute Project
BBS/E/B/0000Q498 The role of the ERK5/BMK1 MAPK pathway in cell growth and oncogenic transformation Principal Investigator 3,711 Institute Project
BBS/E/B/000C0413 To map the organisation of nutrient signalling pathways Co-investigator 3,580,157 Institute Project
BBS/E/B/000C0417 To define the molecular mechanisms that determine cellular and organismal longevity Co-investigator 2,019,869 Institute Project
BBS/E/B/52917498 The role of the ERK5/BMK1 MAPK pathway in cell growth and oncogenic transformation Principal Investigator 84,795 Institute Project
BBS/S/C/2005/13225 MAP Kinase signals that control protein degradation (Funded via Training Grant BB/B511900/1) Principal Supervisor Studentships
BBS/S/K/2003/10151 Regulation of the neurofibromin (NFI) Ras GTPase-activating protein Principal Supervisor 61,513 Studentships
BBS/S/K/2003/10154 Identification of new targets of the ERK5 signalling pathway Principal Supervisor 44,816 Studentships
BBS/S/N/2006/13049 Cell survival signalling by FGF receptors Principal Supervisor 51,322 Studentships
C15785 Regulation of the pro-apoptotic Bcl-2 protein Bim by MAPK pathways Principal Investigator 153,768 Research Grant
C20001 Understanding the spatio-temporal control of Ras deactivation by Ca2+ Principal Investigator 177,916 Research Grant
SAG10012 The role of MAP and SAP kinases in oxidant-induced gene expression and cell senescence Principal Investigator 148,896 Research Grant
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