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Understanding the spatio-temporal control of Ras deactivation by Ca2+
Reference
C20001
Principal Investigator / Supervisor
Dr Simon Cook
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
177,916
Status
Completed
Type
Research Grant
Start date
01/03/2004
End date
28/02/2007
Duration
36 months
Abstract
Ras GTPases operate as binary switches, cycling between an inactive GDP-bound form and an active GTP-bound form at the membrane. They transduce signals into the cytoplasm via effector pathways that regulate cell growth, differentiation and apoptosis. Activation of Ras is enhanced by GEFs; deactivation is accelerated by GAPs. The spatio-temporal regulation of GEFs and GAPs leads to the coordination of Ras signalling events. Recently, a novel role for CA2+ in the control of Ras cycling has emerged with the discovery of CAPRI, a Ca2+ -triggered Ras GAP. The aim of our work is to be better understand how CAPRI functions, and how CA2+ regulates the GTPase activity of Ras in live cell using real-time imaging and Ras biosensor technologies.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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