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Regulation of the pro-apoptotic Bcl-2 protein Bim by MAPK pathways
Reference
C15785
Principal Investigator / Supervisor
Dr Simon Cook
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
153,768
Status
Completed
Type
Research Grant
Start date
29/10/2001
End date
28/10/2004
Duration
36 months
Abstract
Serum withdrawal-induced apoptosis is regulated by the Bc1-2 family of proteins. The pro-apoptotic BH3-only protein Bim is rapidly up-regulated by serum withdrawal and this is required for factor withdrawal-induced death in some cell types. Serum withdrawal-induced death can be prevented by activation of the conditional protein kinase Delta MEKK3:ER* which can activate the ERK, JNK and p38 pathways. Under these conditions Bim expression is repressed and the remaining Bim is phosphorylated. This project will: (i) investigate the role of the ERK, JNK and p38 pathways in regulating the expression of Bim; (ii) identify the phosphorylation sites on Bim and the kinase responsible for phosphorylating them and (iii) determine the biological role of Bim down-regulation and phosphorylation in Delta MEKK3:ER*-induced survival during serum withdrawal.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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