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The role of MAP and SAP kinases in oxidant-induced gene expression and cell senescence
Reference
SAG10012
Principal Investigator / Supervisor
Dr Simon Cook
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
148,896
Status
Completed
Type
Research Grant
Start date
01/11/1998
End date
01/11/2001
Duration
36 months
Abstract
Oxidant-induced damage promotes cell cycle arrest and senescence and activates cellular repair mechanisms. Cell cycle arrest involves the expression of the cyclin- dependent kinase inhibitor p21 whilst repair genes include the ER chaperone protein GRP78/BiP. The signalling pathways by which these genes are regulated are unclear but the MAP kinases and the transcription factor GADD153 are implicated. This study will define 1) the role of the MAP kinase and stress kinase pathways in regulating GADD153 expression, 2) the role of GADD153 in p21 and GRP78 expression, and 3) the role that these components play in promoting cell cycle arrest, senescence and tolerance to oxidative damage.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Initiative on Science of Ageing (SAG) [1998]
Funding Scheme
X – not Funded via a specific Funding Scheme
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