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DNA microarray data analysis and modelling : an integrated approach

ReferenceEGM17736/2
Principal Investigator / Supervisor Professor Ernst Wit
Co-Investigators /
Co-Supervisors		 Professor Ilya Molchanov, Dr Agostino Nobile, Professor Donald Titterington
Institution Lancaster University
DepartmentMathematics and Statistics
Funding typeResearch
Value (£) 56,787
StatusCompleted
TypeResearch Grant
Start date 20/10/2006
End date 19/04/2008
Duration18 months

Abstract

This research programme will combine the expertise of a consortium of biologists, control engineers, computer scientists, mathematicians and statisticians to develop and validate a broad range of mathematical modelling tools for DNA microarray analysis - a key area of post- genomic research. The analysis will focus mainly on large robust microarray datasets obtained from a model bacterium, Streptomyces coelicolor, and a simple model eukaryotic system, herpes virus lytic replication. Our goal is to produce generic tools for modelling changes in cellular transcriptomes following induction of defined cellular processes and gain new biological insight into the gene regulation networks of the two representative model systems. These technologies and appropriate training will be made available to the wider UK functional genomics community. (Joint with grants 17734, 17735, 17737 and 17738).

Summary

unavailable
Committee Closed Committee - Engineering & Biological Systems (EBS)
Research TopicsMicrobiology, Technology and Methods Development
Research PriorityX – Research Priority information not available
Research Initiative Exploiting Genomics: Manufacturing & New Post Tech (EGM) [2001]
Funding SchemeX – not Funded via a specific Funding Scheme
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