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DNA microarray data analysis and modelling : an integrated approach

ReferenceEGM17734
Principal Investigator / Supervisor Professor David Sidney Broomhead
Co-Investigators /
Co-Supervisors		 Professor Colin Smith
Institution The University of Manchester
DepartmentMathematics
Funding typeResearch
Value (£) 623,000
StatusCompleted
TypeResearch Grant
Start date 11/06/2003
End date 10/06/2007
Duration48 months

Abstract

This research programme will develop tools and techniques for mathematical and statistical analysis of DNA microarray data. The analysis will focus mainly on two aspects: pre-processing and visualisation (interpretation) of multivariate microarrays time series data. The principal aim of this project is to complement commercial software tools with advanced normalisation tools, component analysis, fuzzy clustering, time series analysis, projection and non-linear visualisation techniques. In order to develop these generic tools and techniques two large benchmark data sets will be obtained for a simple eukaryotic system (herpes virus) and, later, a challenging bacterial system (Streptomyces). These data sets, tools and techniques, and appropriate training will be made available to the wider UK functional genomics community. (Joint with grants 17735, 17736, 17737 and 17738)

Summary

unavailable
Committee Closed Committee - Engineering & Biological Systems (EBS)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative Exploiting Genomics: Manufacturing & New Post Tech (EGM) [2001]
Funding SchemeX – not Funded via a specific Funding Scheme
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