Award details

Computing infrastructure to underpin integrated and predictive structural and systems biology

Reference	BB/C511305/1
Principal Investigator / Supervisor	Professor Michael Sutcliffe
Co-Investigators / Co-Supervisors	Professor David Leys, Professor Andrew Munro, Professor Nigel Scrutton
Institution	The University of Manchester
Department	Life Sciences
Funding type	Research
Value (£)	100,611
Status	Completed
Type	Research Grant
Start date	01/06/2005
End date	31/05/2006
Duration	12 months

Abstract

This application requests funding to ensure the continued provision of essential computing resource, both low- and high-end, to maintain the underpinning of our internationally renowned, (mainly) BBSRC-supported, problem- and hypothesis-driven interdisciplinary research. The availability of computing resource has proved an important aspect of our existing mature projects. This resource is needed for both the computational biology (bioinformatics/cheminformatics enzymic reaction and ion channel simulations) and structural biology (crystallography) ¿ our work is highly dependent on computing hardware. The work addresses: hydrogen transfer via quantum tunnelling, electron transfer via conformational signalling in multi-component systems, the role of flavin, haem and quinone co-factors in electron transfer, selectivity and specificity of human and Mycobacterium tuberculosis cytochromes P450, and transmembrane ion transport via potassium channels. Our programme of work thus lies at the heart of the BBSRC¿s 10-year vision towards predictive biology, aiming to understand cell function at the molecular level, and lies within the fundamentals of cell biology thematic area of BCB and the `biological catalysis and biomimetic chemistry¿ thematic area of BMS. The computing resource will be maintained by a computer officer in the new 22 million pound Biomedical Sciences Building, into which the applicants will move in September 2004.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Research Equipment Initiative 2004 (RE4) [2004]
Funding Scheme	X – not Funded via a specific Funding Scheme

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