BBSRC Portfolio Analyser

Investigator / Supervisor details

NameProfessor David Leys
Current InstitutionThe University of Manchester
Current DepartmentChemistry
Institution websitehttp://www.man.ac.uk
Previous InstitutionsUniversity of Leicester

Current Awards

ReferenceTitleAward RoleValue £Type
BB/W016745/1 Understanding and application of a biological Kolbe-Schmitt reaction: aromatic C-H activation coupled to CO2 fixation. Principal Investigator 896,895 Research Grant
BB/W019841/1 Optima Analytical Ultracentrifuge for mechanistic insights into complex protein binding events Co-investigator 261,107 Research Grant
BB/X007952/1 Self-sufficient reductive dehalogenases for bioremediation Principal Investigator 524,614 Research Grant

Completed Awards

ReferenceTitleAward RoleValue £Type
B18118 Structures of short-lived physiological electron transfer complexes Principal Investigator 163,852 Research Grant
B18118/2 Structures of short-lived physiological electron transfer complexes Principal Investigator 27,751 Research Grant
B19724 Quantum catalysis in enzymes - beyond the transition state theory paradigm Co-investigator 383,354 Research Grant
B19724/2 Quantum catalysis in enzymes - beyond the transition state theory paradigm Co-investigator 169,002 Research Grant
BB/C003896/1 Atomic analysis of promoting vibrations in the vibrationally assisted model of enzymic hydrogen tunneling. Co-investigator 483,422 Research Grant
BB/C00390X/1 Mechanistic basis of uphill electron transfer and reductive methylation in the human MS¿MSR electron transfer complex Co-investigator 237,482 Research Grant
BB/C00390X/2 Mechanistic basis of uphill electron transfer and reductive methylation in the human MSMSR electron transfer complex Co-investigator 185,304 Research Grant
BB/C00521X/1 The molecular basis of halorespiration Principal Investigator 207,204 Research Grant
BB/C006879/1 Construction of a biotechnologically versatile and stable oxygenase biocatalyst Co-investigator 209,305 Research Grant
BB/C006879/2 Construction of a biotechnologically versatile and stable oxygenase biocatalyst Co-investigator 193,248 Research Grant
BB/C511305/1 Computing infrastructure to underpin integrated and predictive structural and systems biology Co-investigator 100,611 Research Grant
BB/D524608/1 A high brilliance X-ray generator with CCD detector for the Manchester Interdisciplinary Biocentre Co-investigator 199,800 Research Grant
BB/E00833X/1 High pressure & low temperature study of the mechanism of enzymatic hydrogen tunnelling: promoting motions vs multiple kinetically distinct substates Co-investigator 86,082 Research Grant
BB/E010717/1 A generic biocatalytic reaction platform for the stereospecific reduction and oxidation of alkenes Co-investigator 1,704,123 Research Grant
BB/E013007/1 A Biological Pulsed EPR/ENDOR Facility for the Manchester Interdisciplinary Biocentre Co-investigator 240,000 Research Grant
BB/E017010/1 Substrate channelling in catabolism of methylated amines Principal Investigator 681,729 Research Grant
BB/F000537/1 Dynamically-coupled enzyme catalysis: towards a step change in our understanding of enzyme catalysed reactions Co-investigator 2,402,423 Research Grant
BB/F002521/1 Novel routes to catalytic intermediates in the cytochrome P450 catalytic cycle Co-investigator 520,651 Research Grant
BB/F004397/1 Reflection anisotropy spectroscopy as a new tool for linking macromolecular conformation to biological function: applications in biological redox chem Co-investigator 354,969 Research Grant
BB/F00883X/1 Directed evolution approaches to generation of an industrially applicable biocatalyst Co-investigator 587,704 Research Grant
BB/F014252/1 Functional and structural characterization of a novel heme- and micro RNA-binding human protein Co-investigator 688,614 Research Grant
BB/G001383/1 The dynamics of complex cellular machinery required for methionine synthesis in mammalian cells Co-investigator 528,887 Research Grant
BB/G008558/1 A novel regulator of human apoptosis Co-investigator 548,111 Research Grant
BB/G014329/1 Characterization of a superior biocatalyst for pravastatin production Co-investigator 332,908 Research Grant
BB/H000577/1 Domain motion coupled to radical catalysis in ornithine aminomutase Principal Investigator 398,351 Research Grant
BB/I012648/1 Orthogonal riboswitches as tools for controlling gene expression in bacteria Co-investigator 639,275 Research Grant
BB/I019227/1 A fragment based screening approach to rationalizing M. tuberculosis P450 molecular selectivity Co-investigator 411,571 Research Grant
BB/I020160/1 Structure and mechanism of a key enzyme in M. tuberculosis cell envelope biogenesis Co-investigator 391,575 Research Grant
BB/I020764/1 Directed Evolution of Enantiocomplementary Malonate Decarboxylases. Co-investigator 317,821 Research Grant
BB/J015512/1 Industrial chemicals of the monoterpenoid class realised through synthetic biology and pathway engineering Co-investigator 710,975 Research Grant
BB/K001884/1 Molecular reconstruction of flavocytochrome P450 BM3 Co-investigator 436,345 Research Grant
BB/K00199X/1 Rapid Evolution of Enzymes and Synthetic Micro-organisms for the Development of Industrial Biocatalysts Co-investigator 3,604,052 Research Grant
BB/K012290/1 In vivo hydrocarbon production: generation of alpha-olefins using a novel peroxygenase P450 Principal Investigator 93,520 Training Grants
BB/K017802/1 In vivo alpha-olefin production: a sustainable hydrocarbon source Principal Investigator 606,412 Research Grant
BB/L002299/1 Bioengineering of next generation lipoglycopeptide antibiotics Co-investigator 690,996 Research Grant
BB/L014823/1 Multi-purpose instrument for advanced Raman spectroscopy techniques Co-investigator 409,322 Research Grant
BB/L015048/1 Hydrogen/Deuterium Exchange and Ion Mobility Mass Spectrometry to Underpin Research on Protein Interactions Co-investigator 498,947 Research Grant
BB/L015234/1 In vivo production of drop-in biofuels using cytochrome P450 BM3 variants to mimick the activity of the insect P450 CYP4G Principal Investigator 94,126 Training Grants
BB/M000354/1 Innovative Routes to Monoterpene Hydrocarbons and Their High Value Derivatives Co-investigator 3,038,984 Research Grant
BB/M007316/1 Reductive dehalogenases: structure, mechanism and application Principal Investigator 354,495 Research Grant
BB/M011658/1 An advanced multi-purpose instrument for biological ultrafast time resolved spectroscopy Co-investigator 491,200 Research Grant
BB/M017702/1 CENTRE FOR SYNTHETIC BIOLOGY OF FINE AND SPECIALITY CHEMICALS Co-investigator 10,198,943 Research Grant
BB/N006275/1 Molecular mechanism and engineering of P450 peroxygenases for synthetic biology applications Co-investigator 462,081 Research Grant
BB/P000622/1 Exploring the biotechnological potential of the UbiD (de)carboxylase family: novel biochemistry for renewable commodity chemicals Principal Investigator 585,505 Research Grant
BB/P010180/1 Interrogation of the catalytic properties of MhuD - a crucial heme oxygenase in Mycobacterium tuberculosis Co-investigator 448,944 Research Grant
BB/R000069/1 High-throughput micro-fermentation for directed evolution and strain selection in industrial biotechnology Co-investigator 214,394 Research Grant
BB/R009961/1 Construction of potent and specific inhibitors of M. tuberculosis redox enzymes using fragment screening methods Co-investigator 418,298 Research Grant
BB/R01034X/1 Exploiting Halogenase Enzymes: New Reaction Pathways via Enzymatic CH Activation Co-investigator 1,000,545 Research Grant
BB/R013497/1 A versatile proton transfer reaction-mass spectrometry platform for online monitoring of VOCs. Co-investigator 453,088 Research Grant
BB/T017473/1 A nanosecond laser spectroscopy platform for studying light-activated biomolecules Co-investigator 338,507 Research Grant
BB/T017643/1 Glacios cryo-electron microscope for single particle analysis and electron tomography of proteins, complexes and fibrillar assemblies Co-investigator 750,000 Research Grant
BBS/B/03572 Conformational signalling in dynamic multi-domain electron transfer complexes Co-investigator 376,361 Research Grant
BBS/B/03572/2 Conformational signalling in dynamic multi-domain electron transfer complexes Co-investigator 258,478 Research Grant
BBS/B/06288 Molecular enzymology of FprA - a pivotal enzyme in M. tuberculosis redox chemistry Co-investigator 207,930 Research Grant
BBS/B/06288/2 Molecular enzymology of FprA - a pivotal enzyme in M. tuberculosis redox chemistry Co-investigator 116,783 Research Grant
BBS/S/A/2003/12616 The role of conformational sampling in redox enzymology: probing dynamical protein:protein interactions Principal Supervisor 17,317 Studentships
BBS/S/A/2004/10958 Transient protein:protein complex formation in the multi-enzyme glycine cleavage system Principal Supervisor 13,614 Studentships
BBS/S/B/2004/12611 Transient protein-protein complex formation in the multi-enzyme glycine cleavage system Principal Supervisor 34,009 Studentships
BBS/S/H/2005/11961 Exploiting a novel DNA-binding halo-organic sensor for bioremediation Principal Supervisor 49,855 Studentships
BBS/S/P/2003/10344 The role of conformational sampling in redox enzymology: probing dynamical protein: protein interactions. Principal Supervisor 27,456 Studentships
C19031 Elucidating factors controlling enzymic H-tunnelling through structural and kinetic studies of dimethylglycine oxidase Co-investigator 190,784 Research Grant
C19031/2 Elucidating factors controlling enzymic H-tunnelling through structural and kinetic studies of dimethylglycine oxidase Co-investigator 72,367 Research Grant
C19757 Elucidating enzyme mechanism and physiological role of a key P450 enzyme (CYP121) from mycobacterium tuberculosis Co-investigator 196,872 Research Grant
C19757/2 Elucidating enzyme mechanism and physiological role of a key P450 enzyme (CYP121) from mycobacterium tuberculosis Co-investigator 86,688 Research Grant
REI20488 Isothermal titration calorimetry: novel and established applicatons in redox enzymology Co-investigator 29,252 Research Grant
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