Award details

Post-genomic analysis of the proteome of Campylobacter jejuni

Reference	BFP11391
Principal Investigator / Supervisor	Professor Brendan Wren
Co-Investigators / Co-Supervisors
Institution	London Sch of Hygiene and Trop Medicine
Department	Infectious and Tropical Diseases
Funding type	Research
Value (£)	119,316
Status	Completed
Type	Research Grant
Start date	14/07/1999
End date	14/01/2002
Duration	30 months

Abstract

The now complete genome sequence of C. jejuni will facilitate proteome mapping by 2D gel analysis and identification by mass spectroscopy of proteins expressed at significant levels, both under standard conditions and with selected stresses and genetic changes. A consortium of groups will maximise the scope of this approach using shared methods with defined media and manufactured gels to allow comparison of data. Participants will analyse subcellular fractions, other strains, and cells modified by mutation in regulatory genes or subjected to temperature, osmotic, pH and starvation stresses. An overview of protein expression and its significance, more detailed than hitherto available for any other pathogen, is thus within reach. (Joint with grants BFP11390 and BFP11392).

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Biology of Food-Borne Pathogens (BFP) [1997]
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

BFP11390 Post-genomic analysis of the proteome of Campylobacter jejuni

BFP11392 Post-genomic analysis of the proteome of Campylobacter jejuni

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