Award details

Post-genomic analysis of the proteome of Campylobacter jejuni

Reference	BFP11390
Principal Investigator / Supervisor	Professor Charles Penn
Co-Investigators / Co-Supervisors
Institution	University of Birmingham
Department	Sch of Biosciences
Funding type	Research
Value (£)	178,928
Status	Completed
Type	Research Grant
Start date	01/04/1999
End date	01/04/2002
Duration	36 months

Abstract

The now complete genome sequence of C. jejuni will facilitate proteome mapping by 2D gel analysis and identification by mass spectroscopy of proteins expressed at significant levels, both under standard conditions and with selected stresses and genetic changes. A consortium of groups will maximise the scope of this approach using shared methods with defined media and manufactured gels to allow comparison of data. Participants will analyse subcellular fractions, other strains, and cells modified by mutation in regulatory genes or subjected to temperature, osmotic, pH and starvation stresses. An overview of protein expression and its significance, more detailed than hitherto available for any other pathogen, is thus within reach. (Joint with grants BFP11391 and BFP11392).

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Biology of Food-Borne Pathogens (BFP) [1997]
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

BFP11391 Post-genomic analysis of the proteome of Campylobacter jejuni

BFP11392 Post-genomic analysis of the proteome of Campylobacter jejuni

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