Award details

The in vitro assembly and interactions of Salmonella surface structures

Reference	BBS/E/F/00042240
Principal Investigator / Supervisor	Professor Clare Mills
Co-Investigators / Co-Supervisors	Professor Tim Brocklehurst, Professor Jay Hinton, Professor Michael William Peck
Institution	Quadram Institute Bioscience
Department	Quadram Institute Bioscience Department
Funding type	Research
Value (£)	181,166
Status	Completed
Type	Institute Project
Start date	01/04/2006
End date	31/03/2010
Duration	48 months

Abstract

Bacterial attachment to the mucin layer of the gut epithelium is fundamental to the establishment of a stable commensal microflora, and relevant to the progress of infection by important pathogenic bacteria. Using advanced nanobiotechnological techniques the research aims to examine the interaction between mucin and the surface structures of the bacterial cell wall, in order to study their mutual interaction and to identify the molecular basis of the attractive interactions which play a role in bacterial adhesion in vivo. The research also aims to test whether non-specific charge interactions can be used to perturb the adhesion. We will use surface structures derived from Salmonella enterica serovar typhimurium strain SL1344 and from strains of Lactobacillus.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	Animal Health, Microbial Food Safety, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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