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Understanding the spatio-temporal control of Ras deactivation by Ca2+

Reference	BBS/E/B/0000L106
Principal Investigator / Supervisor	Dr Simon Cook
Co-Investigators / Co-Supervisors	Professor Len Stephens
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	110,596
Status	Completed
Type	Institute Project
Start date	01/03/2004
End date	01/03/2007
Duration	36 months

Abstract

Ras GTPases operate as binary switches, cycling between an inactive GDP-bound form and an active GTP-bound form at the membrane. They transduce signals into the cytoplasm via effector pathways that regulate cell growth, differentiation and apoptosis. Activation of Ras is enhanced by GEFs; deactivation is accelerated by GAPs. The spatio-temporal regulation of GEFs and GAPs leads to the coordination of Ras signalling events. Recently, a novel role for Ca2+ in the control of Ras cycling has emerged with the discovery of CAPRI, a Ca2+-triggered Ras GAP. The aim of our work is to better understand how CAPRI functions, and how Ca2+ regulates the GTPase activity of Ras in live cells using real-time imaging and Ras biosensor technologies.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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