Award details

Structures of short-lived physiological electron transfer complexes

Reference	B18118/2
Principal Investigator / Supervisor	Professor David Leys
Co-Investigators / Co-Supervisors	Professor Nigel Scrutton, Professor Michael Sutcliffe
Institution	The University of Manchester
Department	Life Sciences
Funding type	Research
Value (£)	27,751
Status	Completed
Type	Research Grant
Start date	01/02/2006
End date	31/07/2006
Duration	6 months

Abstract

Weakly associated physiological electron transfer (eT) complexes have remained elusive to structural studies. Our work targets understanding of the structural elements of complex formation between redox proteins that undergo large-scale conformational change as a prerequisite to complex assembly, using the ETF proteins as paradigm model systems. The ETFs are highly mobile proteins that interact with a number of key primary dehydrogenases, complexes for which we seek high-resolution structures. Our work will provide atomic insight into a new robust engineering principle for interprotein electron transfer, allowing for specific recognition of multiple redox partners, whilst maintaining efficient electron transfer rates. This will have general implications for physiological, protein-mediated electron transfer.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

B18118 Structures of short-lived physiological electron transfer complexes

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