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Elucidation of the three-dimensional structure of the exocyst complex

Reference	B17173
Principal Investigator / Supervisor	Professor Stephen Baldwin
Co-Investigators / Co-Supervisors	Professor Steve Homans, Professor Simon Phillips, Professor John Trinick
Institution	University of Leeds
Department	Inst of Molecular & Cellular Biology
Funding type	Research
Value (£)	662,372
Status	Completed
Type	Research Grant
Start date	01/10/2002
End date	30/06/2006
Duration	45 months

Abstract

The exocyst is a multisubunit protein complex essential for the trafficking and targeting of secretory vesicles. We propose to solve the three-dimensional structures of the exocyst subunits at atomic resolution, and to elucidate their arrangement in the complex. This will be achieved by a combination of X-ray crystallography, NMR spectroscopy and electron microscopy, using individual expressed subunits and the intact complex isolated from brain, together with surface plasmon resonance and other approaches for mapping subunit interactions. The resultant information will illuminate the molecular mechanism of a process essential for many aspects of eukaryotic cell function, including secretion and synaptogenesis.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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