BBSRC Portfolio Analyser

Award details

A novel genome-wide evaluation of mutants in samonella enterica serovar Typhimurium:application to drug and vaccine development

ReferenceAPG19116
Principal Investigator / Supervisor Professor David Stammers
Co-Investigators /
Co-Supervisors		 Professor Alastair Hawkins, Professor Duncan Maskell
Institution University of Oxford
DepartmentWellcome Trust Centre for Human Genetics
Funding typeResearch
Value (£) 257,040
StatusCompleted
TypeResearch Grant
Start date 01/01/2003
End date 31/12/2006
Duration48 months

Abstract

Objective 1: To generate mutant libraries using two novel genome- wide technologies (TMDH and ODM) developed by Arrow Therapeutics. Objective 2: To identify genes important for bacterial survival, and thereby possible candidates for anti-microbial drug discovery. Attenuated mutants will be evaluated as candidate lives vaccines. The use of S. typhimurium allows the evaluation of survival of mutants in a real infection in an animal host, and thus defines unequivocally the minimum gene set required for virulence and persistence during infection. Objective 3: To select genes identified by TMDH and ODM for recombinant expression and characterisation. This approach utilises a set of proprietary bioinformatics tools along with protein purification, crystallisation methodologies, and structural determination to evaluate rapidly proteins for the drug discovery process. (Joint with grants 19114 and 19115).

Summary

unavailable
Committee Closed Committee - Genes & Developmental Biology (GDB)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative LINK: Applied Genomics (APG) [2000-2004]
Funding SchemeX – not Funded via a specific Funding Scheme
terms and conditions of use (opens in new window)
export PDF file
back to list new search