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A novel genome-wide evaluation of mutants in samonella enterica serovar Tyhimurium: application to drug and vaccine development

ReferenceAPG19115
Principal Investigator / Supervisor Professor Duncan Maskell
Co-Investigators /
Co-Supervisors		 Professor Alastair Hawkins, Professor David Stammers
Institution University of Cambridge
DepartmentVeterinary Medicine
Funding typeResearch
Value (£) 513,704
StatusCompleted
TypeResearch Grant
Start date 07/07/2003
End date 06/01/2007
Duration42 months

Abstract

Objective 1: To generate mutant libraries using two novel genome- wide technologies (TMDH and ODM) developed by Arrow Therapeutics. Objective 2: To identify genes important for bacterial survival, and thereby possible candidates for anti-microbial drug discovery. Attenuated mutants will be evaluated as candidate lives vaccines. The use of S. typhimurium allows the evaluation of survival of mutants in a real infection in an animal host, and thus defines unequivocally the minimum gene set required for virulence and persistence during infection. Objective 3: To select genes identified by TMDH and ODM for recombinant expression and characterisation. This approach utilises a set of proprietary bioinformatics tools along with protein purification, crystallisation methodologies, and structural determination to evaluate rapidly proteins for the drug discovery process. (Joint with grants 19114 and 19116).

Summary

unavailable
Committee Closed Committee - Genes & Developmental Biology (GDB)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative LINK: Applied Genomics (APG) [2000-2004]
Funding SchemeX – not Funded via a specific Funding Scheme
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