BBSRC Portfolio Analyser

Investigator / Supervisor details

NameProfessor Christopher Smales
Current InstitutionUniversity of Kent
Current DepartmentSch of Biosciences
Institution websitehttp://www.kent.ac.uk
Previous Institutions

Current Awards

ReferenceTitleAward RoleValue £Type
BB/T01945X/1 Taiwan Partnering Award: Establishing a CHO Cell Expression System for Animal Vaccine Production Principal Investigator 24,262 Research Grant

Completed Awards

ReferenceTitleAward RoleValue £Type
BB/C006569/1 The molecular responses and functional competence of cultured mammalian cells at sub-physiological temperatures: the cold-shock proteome Principal Investigator 239,619 Research Grant
BB/C504600/1 Chemical and structural integrity of proteins in the glassy state Principal Investigator 185,285 Research Grant
BB/D009375/1 Towards the manipulation of the UPR in mammalian cells to orchestrate cellular re-organization for enhanced monoclonal antibody production Principal Investigator 288,003 Research Grant
BB/E005969/1 Characterization of post-transcriptional constraints that determine rP yield during bioprocessing in mammalian cells Principal Investigator 987,762 Research Grant
BB/E010563/1 Macromolecular metabolosome formation associated with 12-propanediol utilisation Co-investigator 634,062 Research Grant
BB/F018053/1 Enhancing recombinant mRNA translation via interactions with the 3-UTR for improved recombinant protein yields Principal Investigator 72,540 Training Grants
BB/F018908/1 Enhancing global and mRNA specific translation for improved recombinant protein expression in in vitro cultured mammalian cells Principal Investigator 367,628 Research Grant
BB/G010307/1 Integrating upstream host cell line selection and development with improved downstream bioprocessing Principal Investigator 320,391 Research Grant
BB/G016070/1 Development of an integrated platform for production of recombinant protein biopharmaceuticals using disposable processing technology Principal Investigator 74,410 Training Grants
BB/G016593/1 Training for the next generation of Bioprocessing leaders Co-investigator 494,460 Training Grants
BB/G01762X/1 Manipulation of signal peptide sequences for enhanced synthesis and secretion of biotherapeutic monoclonal antibodies Principal Investigator 74,410 Training Grants
BB/H015795/1 Training for the next generation of bioprocessing leaders Co-investigator 333,124 Training Grants
BB/H016058/1 Studentships to enhance research and training in bio processing at kent Co-investigator 150,562 Training Grants
BB/H016082/1 Development of predictive tools and formulations for improved stability and delivery of recombinant protein formulations for bio therapeutic use Principal Investigator 75,281 Training Grants
BB/I010610/1 De novo sequencing of the Chinese Hamster Ovary (CHO) cell genome Co-investigator 85,120 Research Grant
BB/I015876/1 Defining and preventing the mechanisms responsible for disulphide bond reduction of monoclonal antibodies during bioprocessing Principal Investigator 91,932 Training Grants
BB/I015884/1 Development of a CHOK1SV transient expression system for rapid generation of recombinant proteins Principal Investigator 91,932 Training Grants
BB/I020055/1 Defining novel mechanisms of mRNA translational control upon cold-shock in mammalian cells Principal Investigator 374,752 Research Grant
BB/J006408/1 Investigation and manipulation of mTOR cellular signalling to generate novel CHO host cells with high growth and productivity characteristics Principal Investigator 324,214 Research Grant
BB/K004409/1 Unraveling the relationship between IgG yield, recovered/observed clonal numbers and specific integration site on the yield of IgG in CHO cells Principal Investigator 92,173 Training Grants
BB/K012444/1 Development of a minimal expression vector for enhanced recombinant protein expression in mammalian cells Principal Investigator 93,520 Training Grants
BB/K017640/1 Unravelling and engineering the role of trace metals on recombinant therapeutic protein synthesis and heterogeneity from Chinese hamster ovary cells Principal Investigator 517,290 Research Grant
BB/K020943/1 BRIC DOCTORATE PROGRAMME Prediction of stable and transient expression of recombinant proteins from CHO cells based upon translational reprogramming Principal Investigator 93,520 Training Grants
BB/K020951/1 BRIC DOCTORATE PROGRAMME Manipulation and exploitation of microRNAs for enhanced recombinant protein production in CHO cells Principal Investigator 93,520 Training Grants
BB/L002310/1 Tailor-made expression hosts depleted in protease activity for recombinant protein production; PRODuCE (PROtease Depleted CEll line) Principal Investigator 342,147 Research Grant
BB/L013770/1 Bioprocessing Network: BioProNET Principal Investigator 811,631 Research Grant
BB/L026279/1 FLIP Expression of recombinant target antigens for neglected tropical diseases in surrogate organisms Principal Investigator 116,608 Research Grant
BB/M000699/1 13 ERA IB: Investigating NOvel VAluable bio-Therapeutics and Expression systems Principal Investigator 343,941 Research Grant
BB/M002969/1 Development of supramolecular assemblies for enhancing cellular productivity and the synthesis of fine chemicals and biotherapeutics. Co-investigator 3,484,653 Research Grant
BB/M016013/1 Development of predictive tools and formulations for improved stability and delivery of novel peptide and recombinant protein format biotherapeutics Principal Investigator 95,042 Training Grants
BB/M017060/1 Generation of systems for the synthesis of recombinant proteins for use in rapid point of care diagnostics for inflammatory and other diseases Principal Investigator 95,042 Training Grants
BB/M018288/1 A new generation of E. coli expression hosts and tools for recombinant protein production Co-investigator 777,677 Research Grant
BB/N004434/1 Feasibility study with the recombinant protein, rISG65, in a new second generation Rapid Diagnostic Test (RDT) for Sleeping Sickness Principal Investigator 10,546 Research Grant
BB/N012496/1 Development and Commercialisation of a Second Generation Rapid Diagnostic Test (RDT) for Human African Trypanosomiasis (HAT) and other Kinetoplastida Principal Investigator 190,760 Research Grant
BB/N023501/1 Translation of Step-changing Bioprocesses and Expression System Technologies for Next Generation Protein Biologics Production in CHO Cells Principal Investigator 746,256 Research Grant
BB/P025870/1 Partnership to develop compartmentalisation technology Co-investigator 30,612 Research Grant
BB/P02789X/1 GCRF establishment of biopharmaceutical and animal vaccine production capacity in Thailand and neighbouring South East Asian countries Co-investigator 4,090,259 Research Grant
BB/R001731/1 An integrated cell and protein engineering approach to generate enhanced CHO cell platforms for manufacture of difficult to express biopharmaceuticals Principal Investigator 342,550 Research Grant
BB/R013802/1 An advanced bioreactor facility for automated, industry-aligned production of high-value proteins Co-investigator 372,665 Research Grant
BB/S506977/1 Modelling CHO clonal phenotype variance for optimal bioprocessing platform design Principal Investigator 99,034 Training Grants
BB/V011324/1 Generation, characterisation and application of SARS-CoV-2 protein antigens for COVID-19 rapid diagnostic purposes in the hospital and community Principal Investigator 418,025 Research Grant
BBS/S/A/2004/10914 Analysis of the functional competence of mammalian cell systems under diverse culture conditions Principal Supervisor 47,623 Studentships
BBS/S/K/2005/12130 The global cellular responses of in vitro cultured human cells to DNA damage Principal Supervisor 54,224 Studentships
BBS/S/M/2005/12409 The cellular mechanisms governing volumetric productivity in industrially important chinese hamster ovary cell lines Principal Supervisor 49,864 Studentships
BBS/S/M/2006/13028 Development of high concentration monoclonal antibody protein formulations and monitoring procedures Principal Supervisor 51,322 Studentships
BBS/S/M/2006/13132 The role of CCT in recombinant protein production from in vitro cultured mammalian cells Principal Supervisor 51,322 Studentships
LKE13546 The functional competence of animal cells in culture: analysis of the cellular proteome Co-investigator 223,868 Research Grant
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