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The functional competence of animal cells in culture: analysis of the cellular proteome

Reference	LKE13546
Principal Investigator / Supervisor	Dr Peter Klappa
Co-Investigators / Co-Supervisors	Professor Michael Dunn, Professor Christopher Smales
Institution	University of Kent
Department	Sch of Biosciences
Funding type	Research
Value (£)	223,868
Status	Completed
Type	Research Grant
Start date	01/02/2001
End date	01/02/2004
Duration	36 months

Abstract

For engineered bioprocesses employing animal cells in culture, the adaptations to basic cell function that enable improved cell performance are very poorly understood. This programme of research, based on functional genomics, will utilise proteome analysis technology to identify the specific alterations in functional gene expression that enable animal cells in culture to 1) maintain high-level recombinant monoclonal antibody production and 2) proliferate in suspension or attached culture. The outcomes of this research will be an understanding of cell function in the engineering environment and the derivation of a knowledge-based strategy for the identification of rational targets for cell engineering.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	LINK: Engineering & Biological System Committee (EBL) [2000-2003]
Funding Scheme	X – not Funded via a specific Funding Scheme

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