Award details

Resolution of the structure of HBV particles and its use in the design of novel vaccines and antiviral compounds

Reference	SBD07645
Principal Investigator / Supervisor	Professor David Rowlands
Co-Investigators / Co-Supervisors	Professor David Stuart
Institution	University of Leeds
Department	Inst of Molecular & Cellular Biology
Funding type	Research
Value (£)	147,086
Status	Completed
Type	Research Grant
Start date	10/09/1997
End date	10/09/2000
Duration	36 months

Abstract

A variety of techniques will be employed to provide suitable crystals of hepatitis B core particles to obtain a high resolution structure. This will then be used to direct mutagenesis experiments designed to investigate the factors influencing core particle assembly, virus RNA/pol encapsidation and the surface protein associations which promote virion assembly. An understanding of these interactions at the atomic level should be valuable for the design of potential antiviral inhibitors. Also, chimeric cores including genetically fused epitopic domains from foreign sources will be examined to understand details of antigenic structure and to assist in the design of novel recombinant vaccines. Finally, core particles decorated with receptor binding domains from other viruses and proteins will be used to study ligand/receptor interactions and to identify inhibitory molecules. (Joint with grant SBD07644).

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Structural biology and design applications (SBD) [1996]
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

SBD07644 Resolution of the structure of HBV particles and its use in the design of novel vaccines and antiviral compounds

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