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Structure-based inhibitor design and vaccine development using carbohydrate-binding bacterial toxins

Reference	SBD07527
Principal Investigator / Supervisor	Professor Steve Homans
Co-Investigators / Co-Supervisors	Dr Rob Field, Professor James Naismith, Professor Richard Randall
Institution	University of Leeds
Department	Inst of Molecular & Cellular Biology
Funding type	Research
Value (£)	236,406
Status	Completed
Type	Research Grant
Start date	01/10/1997
End date	01/04/2001
Duration	42 months

Abstract

Enteropathogenic Escherichia coli, in common with a variety of other pathogenic bacteria produce cytotoxins associated with diarrhoeal diseases. In addition to presenting serious problems in the Third World, these toxins are responsible for conditions such as haemolytic uraemic syndrome (HUS) in infants, which is the largest cause of kidney failure in this age group. We plan to use structural information on the carbohydrate-binding B subunits of these toxins in a multidisciplinary programme aimed at inhibitor design and to exploit the carbohydrate-binding activity of these toxins as a general tool in the design of potential mucosal vaccines.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Structural biology and design applications (SBD) [1996]
Funding Scheme	X – not Funded via a specific Funding Scheme

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