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Cambridge and East Anglia Centre: The Structural Biology of cell signalling in animals plants and microbes

ReferenceSB11274
Principal Investigator / Supervisor Dr Denis Alexander
Co-Investigators /
Co-Supervisors		 Professor Sir Michael Berridge, Dr Martin Bootman, Dr Peter Kilshaw, Dr Peter Lipp, Professor Robert Moore, Dr Martin Turner
Institution Babraham Institute
DepartmentBabraham Institute Department
Funding typeResearch
Value (£) 195,072
StatusCompleted
TypeResearch Grant
Start date 06/09/1999
End date 05/09/2004
Duration60 months

Abstract

The objective is to study the structural biology of signalling, including receptor activation at the cell surface, and signal transduction in the cytoplasm, leading to control of transcription. These processes involve multicomponent complexes, some of which are stable and others transient. We will study the structures of microbial, plant and mammalian systems, with a view to comparative analyses. We propose the establishment of linked laboratories in microbial, animal and plant protein expression and preparation, nuclear magnetic resonance, protein crystallography, mass spectroscopy, microcalorimetry and computing, exploiting strengths and bringing to critical mass expertise in structural and cell biology at Cambridge University, University of East Anglia, John Innes Centre and Babraham Institute. (Joint with grants SB11271, SB11272 and SB11275).

Summary

unavailable
Committee Closed Committee - Biomolecular Sciences (BMS)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative Structural Biology (SB) [1997-1998]
Funding SchemeX – not Funded via a specific Funding Scheme
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