Award details

Dissecting the mechanisms of human cell senescence

Reference	SAG09947
Principal Investigator / Supervisor	Professor David Kipling
Co-Investigators / Co-Supervisors	Professor Richard Faragher, Professor David Wynford-Thomas
Institution	Cardiff University
Department	Division of Clinical Laboratory Science
Funding type	Research
Value (£)	149,208
Status	Completed
Type	Research Grant
Start date	01/03/1999
End date	01/03/2002
Duration	36 months

Abstract

The progressive accumulation of senescent mammalian cells is a plausible biological mechanism for the ageing of regenerative tissue. Understanding the mechanism by which cells enter senescence will provide valuable insights into the means by which they accumulate in ageing bodies. Strong evidence exists that senescence in some cell types is telomere dependant. However there is also good evidence from both humans and rodents that a telomere-independant pathway exists. The applicant seeks support to determine the relevance of both pathways in model human cell systems and to evaluate methodologies aimed at achieving the stable ablation of senescence. (Joint with 107/SAG99048 - Dr. R Faragher).

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Initiative on Science of Ageing (SAG) [1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

SAG09948 Dissecting the mechanisms of human cell senescence

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