Award details

Assessing the role of the senescent fibroblast in aged skin pathology

ReferenceSAG09935
Principal Investigator / Supervisor Dr Ian Kill
Co-Investigators /
Co-Supervisors
Institution Brunel University London
DepartmentBiological Sciences
Funding typeResearch
Value (£) 72,085
StatusCompleted
TypeResearch Grant
Start date 01/10/1998
End date 01/10/2001
Duration36 months

Abstract

The aim of the proposed work is to use a combination of in vitro and in vivo models to test the hypothesis that senescent cells contribute to aged pathology. Acellular fibrous dermal collagen (FDC) preparations maintain typical matrix architecture. By culturing young of senescent rat dermal fibroblasts with FDC derived from young or geriatric rats, or FDC seeded with young or senescent cells, will be grafted into full thickness loss skin wounds in chests of young rats. Histological and biochemical analyses of the grafts after two and four weeks in situ will reveal whether cell age or matrix age is the main cause underlying the changes that are characteristic of aged skin. (This project is a joint application with SAG09932).

Summary

unavailable
Committee Closed Committee - Genes & Developmental Biology (GDB)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative Initiative on Science of Ageing (SAG) [1998]
Funding SchemeX – not Funded via a specific Funding Scheme
terms and conditions of use (opens in new window)
export PDF file