Award details

Assessing the role of the senescent fibroblast in aged skin pathology

Reference	SAG09932
Principal Investigator / Supervisor	Dr Ian Kill
Co-Investigators / Co-Supervisors	Dr R Oliver
Institution	Brunel University London
Department	Biological Sciences
Funding type	Research
Value (£)	161,819
Status	Completed
Type	Research Grant
Start date	23/11/1998
End date	23/11/2001
Duration	36 months

Abstract

The aim of the proposed work is to use a combination of in vitro and in vivo models to test the hypothesis that senescent cells contribute to aged pathology. Acellular fibrous dermal collagen (FDC) preparations maintain typical matrix architecture. By culturing young of senescent rat dermal fibroblasts with FDC derived from young or geriatric rats, or FDC seeded with young or senescent cells, will be grafted into full thickness loss skin wounds in chests of young rats. Histological and biochemical analyses of the grafts after two and four weeks in situ will reveal whether cell age or matrix age is the main cause underlying the changes that are characteristic of aged skin. (This project is a joint application with SAG09935).

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Initiative on Science of Ageing (SAG) [1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

SAG09935 Assessing the role of the senescent fibroblast in aged skin pathology

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