Award details

Changes in the host transcriptome during morbillivirus infection as determinants of virulence and host specificity

Reference	S20214
Principal Investigator / Supervisor	Professor Francesco Falciani
Co-Investigators / Co-Supervisors	Dr Michael Baron
Institution	University of Birmingham
Department	Sch of Biosciences
Funding type	Research
Value (£)	4,340
Status	Completed
Type	Research Grant
Start date	01/04/2004
End date	31/03/2007
Duration	36 months

Abstract

The morbilliviruses are negative-strand RNA viruses which cause disease in a variety of hosts; members include measles virus (MV) of humans and rinderpest virus (RPV) of cattle. Although the morbilliviruses are restricted in the host range in which they cause disease, they all seem able to infect most mammalian species at least subclinically. Our hypothesis is that it is differences in the host response to infection that leads to differences in the observed outcomes, and therefore the host-range restriction of the diseases caused by these viruses. We will study the effects on the host transcriptome of infection by virulent RPV using a bovine microarray, and compare this with the effects of infection by avirulent RPV or virulent MV. (Joint with grant number 20213).

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

S20213 Changes in the host transcriptome during morbillivirus infection as determinants of virulence and host specificity

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