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Changes in the host transcriptome during morbillivirus infection as determinants of virulence and host specificity

ReferenceS20213
Principal Investigator / Supervisor Dr Michael Baron
Co-Investigators /
Co-Supervisors
Institution The Pirbright Institute
DepartmentDiv of Microbiology Pirbright
Funding typeResearch
Value (£) 194,082
StatusCompleted
TypeResearch Grant
Start date 15/01/2004
End date 14/05/2008
Duration52 months

Abstract

The morbilliviruses are negative-strand RNA viruses which cause disease in a variety of hosts; members include measles virus (MV) of humans and rinderpest virus (RPV) of cattle. Although the morbilliviruses are restricted in the host range in which they cause disease, they all seem able to infect most mammalian species at least subclinically. Our hypothesis is that it is differences in the host response to infection that leads to differences in the observed outcomes, and therefore the host-range restriction of the diseases caused by these viruses. We will study the effects on the host transcriptome of infection by virulent RPV using a bovine microarray, and compare this with the effects of infection by avirulent RPV or virulent MV. (Joint with grant number 20214).

Summary

unavailable
Committee Closed Committee - Animal Sciences (AS)
Research TopicsAnimal Health, Immunology, Microbiology
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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