Award details

The role of the nuclear receptor cofactor NRIP1 in male fertility

Reference	S15893
Principal Investigator / Supervisor	Professor Malcolm Parker
Co-Investigators / Co-Supervisors	Professor Stuart Milligan
Institution	Imperial College London
Department	Imperial College London Department
Funding type	Research
Value (£)	183,596
Status	Completed
Type	Research Grant
Start date	11/02/2002
End date	11/02/2005
Duration	36 months

Abstract

Current understanding of the mechanisms by which steroids control the expression of specific genes is limited by lack of information about the function of transcriptional cofactors acting as coactivators or corepressors. We will study the role of Nrip1 (RIP140), a nuclear receptor corepressor particularly implicated in oestrogen action. Nrip1 is essential for normal maturation of spermatozoa and is selectively expressed within the testis and male tract. We will investigate the role of Nrip1, identify genes whose expression is modulated by the protein and characterise the signalling pathways involved. This work will provide a novel insight into the role of corepressors in modulating steroid action and their role in male fertility. (Joint with grant 29/S15887).

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

S15887 The role of the nuclear receptor cofactor NRIP140 in male fertility

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search