Award details

The role of the nuclear receptor cofactor NRIP140 in male fertility

Reference	S15887
Principal Investigator / Supervisor	Professor Stuart Milligan
Co-Investigators / Co-Supervisors	Professor Malcolm Parker
Institution	King's College London
Department	GKT School of Biomedical Sciences
Funding type	Research
Value (£)	191,808
Status	Completed
Type	Research Grant
Start date	01/02/2002
End date	01/02/2005
Duration	36 months

Abstract

Current understanding of the mechanisms by which steroids control the expression of specific genes is limited by lack of information about the function of transcriptional cofactors acting as coactivators or corepressors. We will study the role of Nrip1 (RIP140), a nuclear receptor corepressor particularly implicated in oestrogen action. Nrip1 is essential for normal maturation of spermatozoa and is selectively expressed within the testis and male tract. We will investigate the role of Nrip1, identify genes whose expression is modulated by the protein and characterise the signalling pathways involved. This work will provide a novel insight into the role of corepressors in modulating steroid action and their role in male fertility. (Joint with grant 28/S15893).

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

S15893 The role of the nuclear receptor cofactor NRIP1 in male fertility

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