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Signalling mechanisms of vomeronasal receptors and the molecular characterisation of pheromonal ligands

Reference	S15797
Principal Investigator / Supervisor	Professor Eric Keverne
Co-Investigators / Co-Supervisors	Dr Piers Emson, Dr Lynda Sellers
Institution	University of Cambridge
Department	Zoology
Funding type	Research
Value (£)	216,760
Status	Completed
Type	Research Grant
Start date	01/02/2002
End date	31/05/2005
Duration	40 months

Abstract

Pheromones incite profound effects on mammalian social and reproductive behaviours, yet the mechanisms through which they induce these physiological changes are poorly defined. In the proposed study, the signalling machinery utilised by the three distinct receptor families that have recently been cloned and identified as putative pheromone chemosensors (V1R, V2R, V3R) will be characterised and compared. Analysis will be made using recombinant expression systems as well as tissue slices from the vomeronasal organ. Fractionation of urinary pheromones will enable the molecular characterisation of specific ligand-receptor interactions for a given VR to be defined and to establish their topographical maps at the level of the vomeronasal organ. (Joint with grant 202/S16044).

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

S16044 Signalling mechanisms of vomeronasal receptors and the molecular characterisation of pheromonal ligands

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