Award details

Defining the repertoire of the microneme and rhoptry organelles of the apicomplexan parasite Eimeria tenella by cell map proteomics

Reference	S15362
Principal Investigator / Supervisor	Professor Michael Dunn
Co-Investigators / Co-Supervisors	Professor Fiona Tomley
Institution	King's College London
Department	Institute of Psychiatry
Funding type	Research
Value (£)	31,520
Status	Completed
Type	Research Grant
Start date	01/09/2002
End date	01/09/2005
Duration	36 months

Abstract

Micronemes and rhoptries are essential for invasion by apiciomplexan parasites, but only a small number of proteins are characterised and their precise function is largely unknown. The protein repertoire of these two important secretory organelles will be identified for the first time using Eimeria tenella, a serious pathogen of chickens which is also an excellent model for biochemical studies on micronemes and rhoptries. Identification of the total protein content of micronemes and rhoptries will underpin studies on the biology of host cell invasion in E. tenella and lead to the identification of potential therapeutic targets against coccidiosis. Since structural homology and functional complementarity exists between organelle proteins of different genera, data from this project will also lead to the identification of novel organelle proteins in other apicocomplexans. (Joint with grant 201/S15358).

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

S15358 Defining the repertoire of the microneme and rhoptry organelles of the apicomplexan parasite Eimeria tenella by cell map proteomics

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