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Immunological tolerance against ALV-J infection in meat-type chickens: role of novel endogenous retroviral elements
Reference
S13847
Principal Investigator / Supervisor
Professor Venugopal Nair
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
Div of Immunology Compton
Funding type
Research
Value (£)
157,472
Status
Completed
Type
Research Grant
Start date
01/02/2001
End date
01/02/2004
Duration
36 months
Abstract
Avian leukosis virus subgroup (ALV-J), first isolated by our group in the late 1980s from the UK, has since spread rapidly world-wide and is one of the major diseases affecting the poultry industry today. In the field, the disease associated with ALV-J occurs only in chickens selectively bred for meat production and this was related to the specific immunological tolerance of meat- type chickens to ALV-J infection. Although the exact basis for the tolerance is not clear, recently we identified novel endogenous retroviral elements in the chicken genome with 98 percent homology to the envelope gene of ALV-J. The proposed project is to examine the role of these novel elements in the induction of tolerance against ALV-J in meat-type chickens.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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