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Investigation of the coronavirus transcription mechanism
Reference
S12883
Principal Investigator / Supervisor
Professor Julian Hiscox
Co-Investigators /
Co-Supervisors
Institution
University of Reading
Department
Animal and Microbial Sciences
Funding type
Research
Value (£)
152,220
Status
Completed
Type
Research Grant
Start date
18/07/2000
End date
18/07/2003
Duration
36 months
Abstract
Avian infectious bronchitis virus (IBV), a coronavirus, is a major pathogen of economic importance for the poultry industry. The molecular basis for the tropism of IBV is unknown. However, as with many other viruses tropism may be determined post-entry, possibly at the level of transcription. Experimental data to elucidate the pathway used by the coronavirus replicase to synthesise the sgRNAs has been interpreted in the light of two competing models, leader primed transcription and discontinuous transcription during negative strand synthesis. Several advances both technological and methodological should allow the precise molecular dissection of the coronavirus transcription pathway. The focus of this research project is to determine how IBV transcribes its subgenomic mRNAs and to investigate what viral and host factors are involved in this process.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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