Award details

Processing and inactivation of nematode neuropeptides by aminopeptidases: a functional genomics approach

Reference	S12813
Principal Investigator / Supervisor	Professor Elwyn Isaac
Co-Investigators / Co-Supervisors	Professor David Coates, Professor Nigel Hooper
Institution	University of Leeds
Department	Inst of Integrative & Comparative Biolog
Funding type	Research
Value (£)	178,704
Status	Completed
Type	Research Grant
Start date	05/06/2000
End date	05/06/2003
Duration	36 months

Abstract

Neuropeptides are important transmitters/modulators in nematode sensory and locomotory pathways and components of the peptidergic system are candidate targets for anti-nematode drugs. The aim of this project is to improve our understanding of the role of cell-surface aminopeptidases in determining the biological activity of nematode neuropeptides involved n the control of behaviour of the free-living Caenorhabditis elegans. Homology searches of the entire C. elegans genome has identified 11 genes predicted to code for proteins with conserved aminopeptidase motifs. We will determine the temporal/spatial expression patterns of aminopeptidases in C. elegans; express and purify recombinant aminopeptidases for detailed enzymatic assays; study the gene-specific loss-of-function phenotypes in worms subjected to RNA interference and in deletion mutants.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search