Award details

Expression and function of semaphorins and neuropilins in the mature sensory nervous system

Reference	S11965
Principal Investigator / Supervisor	Professor Stephen Hunt
Co-Investigators / Co-Supervisors	Dr Michelle Robinson
Institution	University College London
Department	Cell and Developmental Biology
Funding type	Research
Value (£)	167,436
Status	Completed
Type	Research Grant
Start date	06/08/1999
End date	04/10/2004
Duration	62 months

Abstract

Semaphorins and neuropilins play an important role in axon guidance during development. We have found that neuropilin-1 becomes re-expressed in adult rat sensory neurons after injury. Here we want to test the hypothesis that semaphorins and neuropilins play an important role in the adult and may be involved in some of the mechanisms of remodelling and plasticity that are known to occur in several pathophysiological states. We propose a detailed and comprehensive analysis of the expression and regulation of semaphorins and neuropilins, both in the normal adult rat and in a number of pathological conditions. (Joint with award S11963.)

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

S11963 Expression and function of semaphorins and neuropilins in the mature sensory nervous system

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