Award details

Expression and function of semaphorins and neuropilins in the mature sensory nervous system

Reference	S11963
Principal Investigator / Supervisor	Professor Stephen McMahon
Co-Investigators / Co-Supervisors	Dr Elizabeth Bradbury
Institution	King's College London
Department	GKT School of Biomedical Sciences
Funding type	Research
Value (£)	172,132
Status	Completed
Type	Research Grant
Start date	11/10/1999
End date	11/04/2003
Duration	42 months

Abstract

Semaphorins and neuropilins play an important role in axon guidance during development. We have found that neuropilin-1 becomes re-expressed in adult rat sensory neurons after injury. Here we want to test the hypothesis that semaphorins and neuropilins play an important role in the adult and may be involved in some of the mechanisms of remodelling and plasticity that are known to occur in several pathophysiological states. We propose a detailed and comprehensive analysis of the expression and regulation of semaphorins and neuropilins, both in the normal adult rat and in a number of pathological conditions. (Joint with award S11965.)

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

S11965 Expression and function of semaphorins and neuropilins in the mature sensory nervous system

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