Award details

Parathyroid hormone-related protein (PTHrP) and calcium homeostasis in teleost fish

Reference	S09874
Principal Investigator / Supervisor	Dr P Ingleton
Co-Investigators / Co-Supervisors	Professor Richard Balment, Professor Barry Brown
Institution	University of Sheffield
Department	Division of Clinical Sciences North
Funding type	Research
Value (£)	104,272
Status	Completed
Type	Research Grant
Start date	01/04/1999
End date	31/05/2002
Duration	38 months

Abstract

The project combines the complementary expertise of two laboratories (Manchester and Sheffield) in an investigation of the role of Parathyroid Hormone related Protein (PTHrP) as a hypercalcaemic factor in teleost fish Ca homeostasis. Using the euryhaline flounder in vivo studies will establish the tissue source of circulating PTHrP and physiological control of PTHrP secretion, blood peptide concentration and target tissue action. Isolation and sequencing of PTHrP and homologous RIA development will be coupled with cloning of flounder genes for PTHrP, PTHrP receptor and the calcium-sensing receptor (CaR). Tissue PTHrP and PTHrP-receptor expression will be established along with possible coincident CaR expression. The caR mediation of the modulatory role of blood [Ca] on both PTHrP secretion and PTHrP target tissue action will be defined by in vivo and in vitro studies. (Joint with 34/S09873).

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

S09873 Parathyroid hormone-related protein (PTHrP) and calcium homeostasis in teleost fish

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