Award details

The physiological roles of two Drosophila peptidases (Ance and Acer) in peptide hormone metabolism

Reference	S09564
Principal Investigator / Supervisor	Professor Elwyn Isaac
Co-Investigators / Co-Supervisors	Professor David Coates, Dr Alan Shirras
Institution	University of Leeds
Department	Inst of Integrative & Comparative Biolog
Funding type	Research
Value (£)	140,932
Status	Completed
Type	Research Grant
Start date	01/09/1998
End date	01/09/2001
Duration	36 months

Abstract

Ance and Acer are two Drosophila genes coding for enzymes related to human angiotensin-converting enzyme, ACE. The precise role of these peptidases is now known, but the importance of Ance is indicated by the existence of two mutant alleles, one of which is embryonic lethal, the other is semi- lethal and male infertile. In vitro studies indicate a new role for Ance in pro-hormone processing, however in vivo substrates have not been defined for either Ance or Acer. We will identify in vivo substrates of Ance and Acer, combining modern analytical techniques with molecular approaches. The effects of enzyme inhibitors, mutations and overexpression on Drosophila development and physiology will be studied to determine the physiological role of Ance and Acer. (Joint with grant S09563).

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

S09563 The physiological roles of two Drosophila peptidases (Ance and Acer) in peptide hormone metabolism

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