Award details

Quantitative analysis of flavonoids, vitamins, amino acids and cationic peptides; determination of substrate specificity and purification of oligosaccharides using HPLC

Reference	REI20567
Principal Investigator / Supervisor	Professor Georg Lietz
Co-Investigators / Co-Supervisors	Professor Dianne Ford, Professor Harry Gilbert, Dr Judith Hall, Professor John Mathers, Professor Chris Seal
Institution	Newcastle University
Department	School of Medical Education Development
Funding type	Research
Value (£)	29,176
Status	Completed
Type	Research Grant
Start date	31/10/2003
End date	31/07/2004
Duration	9 months

Abstract

The state-of-the-art HPLC requested under this bid will support the work of several researchers through identification and quantification of a range of biomolecules. These include: Dr G Lietz: quantification of beta-carotene, vitamin A, homocysteine and folate in foods and blood samples in studies concerned with understanding the molecular basis of inter-individual variation in responses to nutrients. Dr J Hall: identification and quantification of novel antimicrobial peptides from the avian intestine which may explain susceptibility/resistance of poultry to colonisation by the human enteropathogen Salmonella sp. Dr Dianne Ford: identification and quantification of isoflavones and their aglycones in studies of inter-individual differences in absorption and metabolism by human volunteers. Professor Harry Gilbert: identification, purification and quantification of a range of oligosaccharides in studies of hydrolysis and synthesis of glycosidic bonds with particular reference to substrate specificity and catalytic activity. Professor John Mathers: quantification of homocysteine, folate and other metabolites in the blood of elderly persons participating in a new cohort study of the biological factors (diet: genotype interactions) influencing healthy ageing (Northeast 85+ study). Dr Chris Seal: identification and quantification of a range of compounds with antioxidant properties in foods and blood samples in studies of bioprotective effects of specific foods include wholegrain foods.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Research Equipment Initiative 2003 (RE2) [2003]
Funding Scheme	X – not Funded via a specific Funding Scheme

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