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A central regulator of environmental stress responses in Streptomyces coelicolor

Reference	PRS12164
Principal Investigator / Supervisor	Professor Mark Buttner
Co-Investigators / Co-Supervisors
Institution	John Innes Centre
Department	John Innes Centre Department
Funding type	Research
Value (£)	192,274
Status	Completed
Type	Research Grant
Start date	01/09/1999
End date	31/03/2004
Duration	55 months

Abstract

We have identified a locus (sig1) that functions as a central regulator of stress responses in S. coelicolor and, in collaboration with Prof. Charles Thompson, we have shown that two sigma factors, sigma37 and sigma52 are produced from the sig1 gene, arising from alternative translation start codons. The aims of the proposed work are (i) to use proteome analysis to identify proteins whose expression is controlled by sigma37 and/or sigma52 (ii) to investigate the role of orfX in the regulation of sigma27/52 activity (iii) to demonstrate Prs1 anti-sigma factor activity and to investigate its interaction with both sigma52 and sigma37 (iv) to identify the mechanism which regulates the activity of Prs1 (v) to understand the negative role of sig1 in the regulation of CatA expression, and (vi) to begin to investigate the roles of other identified B. subtilis sigmaB -like factors in S. coelicolor.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Prokaryotic Responses to Environmental Stress (PRS) [1999]
Funding Scheme	X – not Funded via a specific Funding Scheme

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