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Genetic characterisation of new sporulation genes in Streptomyces coelicolor A3(2)
Reference
P07658
Principal Investigator / Supervisor
Professor Mark Buttner
Co-Investigators /
Co-Supervisors
Institution
University of East Anglia
Department
Biological Sciences
Funding type
Research
Value (£)
161,668
Status
Completed
Type
Research Grant
Start date
01/10/1997
End date
01/05/2001
Duration
43 months
Abstract
It is clear from recent analysis that there are many mutations that block development of S. coelicolor after sporulation septum formation, or cause aberrant placement of the septum, which do not correspond to known sporulation (whi) loci. The aim of this work is to define, map and clone new whi loci which, in genetic terms, bridge the gap in the developmental pathway between the early stages of sporulation, as represented by the whiA, whiB, whiG, whiH, whil and whiJ loci, and the late stages of sporulation, as represented by sigF. The work will take advantage of the technological advances made possible by the recent construction of an ordered cosmid library for S. coelicolor, which will allow this important target to be achieved with a relatively small investment of resources.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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