Award details

Cell-to-cell signalling in Pseudomonas and Erwinia: novel opportunities in microbial cell technology

Reference	P06049
Principal Investigator / Supervisor	Professor George Salmond
Co-Investigators / Co-Supervisors
Institution	University of Cambridge
Department	Biochemistry
Funding type	Research
Value (£)	346,851
Status	Completed
Type	Research Grant
Start date	13/03/1996
End date	31/01/2000
Duration	46 months

Abstract

In keeping with the momentum derived from the previous BBSRC-funded research programme, we propose to explore two interlinked core areas. These are i) exploitation of the genetic characterisation of carbapenem biosynthesis and regulation through the continued biochemical characterisation of the cognate enzymatic pathway and ii) the detailed elucidation of the complex regulatory mechanisms that underlie cell-cell signalling (quorum sensing) and the production of secondary metabolites. Secondary metabolite production in both Erwinia (e.g. carbapenems) and Pseudomonas (e.g. exoenzymes) are biotechnologically relevant and in both organisms quorum sensing plays a central regulatory role. We believe that both core areas offer outstanding opportunities for the exploitation of novel microbial cell technology.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

P06045 Cell-cell signalling in Pseudomonas and Erwinia: novel opportunities in microbial cell technology

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